IndraLab

Statements

TNF increases the amount of CYLD. 14 / 17
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"At this time, the underlying mechanism by which TNFalpha up-regulates the expression of CYLD is not clear."
28900035
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"Such a function of CYLD was suggested by the finding that the expression of CYLD is induced by proinflammatory cytokines, TNF-alpha and IL-1beta, and the Gram negative bacterium Haemophilus influenzae."
19373246
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"Moreover, TNFα treatment increased the expression of CFLAR (cFLIP) and CYLD, which in turn suppressed the expression of genes associated with apoptosis (RIPK1 and RIPK3) and enhanced the expression of genes associated with necroptosis (MLKL and DNM1L) (Figure 2F)."
34700029
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"As shown in Fig. 1 , the protein level of endogenous CYLD was highest in THP-1 cells among these vascular cells and was upregulated by IL-1β and TNFα in HAECs and THP-1 cells but not in HASMCs."
30554661
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"One possibility is that Cyld expression is upregulated by TNF and IL-1beta, via IKK-NF-kappaB pathway XREF_BIBR, XREF_BIBR, XREF_BIBR triggers its association with Itch."
22057290
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"Indeed, both TNF-alpha and non typeable Haemophilus influenzae (NTHi), a common Gram negative bacterial pathogen that causes respiratory infections, can upregulate CYLD expression, suggesting that CYL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20347313
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"32 In mouse bone marrow derived macrophages, CYLD expression is strongly induced by RANKL, but not by TNF-alpha or LPS."
19373246
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"The expression of CYLD and NF-kappaB mRNAs in HSG cells was increased by TNF-alpha."
18497946
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"Similarly, mRNA levels of CYLD or cIAP1, which are involved in the regulation of complex I activity (Annibaldi & Meier, 2018), were not significantly induced by TNF or reduced in RelA-knockout cells (Fig XREF_FIG)."
33314666
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"Our data showed for the first time that TNF-α treatment induced significantly down-expression of CYLD at 15 min and the level recovered to normal at 30 min."
28082198
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"Several early reports indicated that CYLD expression was upregulated by LPS or TNF-α treatment [31–33]."
34092220
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"For example, although TNF-alpha stimulates CYLD expression in HeLa cells, human bronchial epithelial cells, and human aortic endothelial cells, XREF_BIBR - XREF_BIBR it fails to induce CYLD expression in 293 cells."
19373246
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"In the present study, we found that both LPS and TNF-α did not increase the mRNA level of CYLD."
34092220
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"Moreover, endogenous expression of CYLD is upregulated by TNF, IL-1 and TLR2 ligands in an NF-κB-dependent way, supporting a negative-feedback role for CYLD in the NF-κB pathway [32,33] ."
16982211