IndraLab

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USP4 decreases the amount of TP53. 3 / 4
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"Previous studies have found that USP4 can inhibit p53 transcription and pro-apoptotic functions by stabilizing HDAC2 [17], whereas the deubiquitinase USP4 stabilizes Twist1 protein to promote lung cancer stemness [18]."
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"In fact, our data show that USP4 inhibited the levels of acetylation but not protein expression of p53 (XREF_FIG)."
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"For instance, USP4 was shown to reduce p53 levels via deubiquitination of ARF-BP1 XREF_BIBR."
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