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OTUD3 binds MAVS. 4 / 4
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"Furthermore, OTUD3 immunoprecipitated together with MAVS in untransfected peritoneal macrophages, BMDMs, and MEFs ( Figure 3 H), which showed that endogenous MAVS is associated with OTUD3."
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"19 According to the study showing that OTUD3 associates with mitochondrial antiviral-signaling protein (MAVS) to suppress anti-RNA viral immune response, 17 we also performed coIP experiments using F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Interestingly, a time-course analysis of SeV infection showed that, concomitant with the increased binding of MAVS to TRIM31, the association between MAVS and OTUD3 remained actually constant ( Figure[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Studies have found that OTUD3 can directly bind to MAVS and remove its K63-linked ubiquitin chains to turn off the antiviral signal ( xref )."
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