IndraLab

Statements

Antagonist inhibits NLRP3. 3 / 3
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eidos
"Therefore , antagonists or P2X7 deletion can inhibit NLRP3 formation and inflammatory effects on microglial cells ( Wang et al. 2020b ) ."
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sparser
"Suppression of AGEs-RAGE pathway protected the kidney from pro-inflammatory injury, in particular, in renal glomeruli during DM ( xref ; xref ; xref ) and antagonists of RAGE inhibited AGEs-induced NLRP3 inflammasome activation and consequent chronic renal injury ( xref )."
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reach
"Among the latter, anakinra is the recombinant form of the IL-1 receptor antagonist, known to inhibit NLRP3 via blockade of the IL-1 receptor I. Anakinra is currently used to treat a wide range of diseases that goes beyond its approved indications for rheumatoid arthritis and cryopyrin-associated periodic syndromes, to encompass cancer and chronic inflammatory diseases 9 ."
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