IndraLab

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Antagonist inhibits NLRP3. 5 / 5
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"NLRP3 inflammasome activation, IL-1β production, and pyroptosis were significantly increased in Con A-induced AIH mice. xref Recombinant human IL-1 receptor antagonists can inhibit NLRP3 in AIH by inhibiting ROS production and mitochondrial dysfunction in liver tissue. xref The activation of NLRP3 may involve the NF-κB ( xref ) and the protein kinase A (PKA) signaling pathways."
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"Therefore , antagonists or P2X7 deletion can inhibit NLRP3 formation and inflammatory effects on microglial cells ( Wang et al. 2020b ) ."
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"These findings indicate different kinetic modes of AII inhibition by these two antagonists."
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"Suppression of AGEs-RAGE pathway protected the kidney from pro-inflammatory injury, in particular, in renal glomeruli during DM ( xref ; xref ; xref ) and antagonists of RAGE inhibited AGEs-induced NLRP3 inflammasome activation and consequent chronic renal injury ( xref )."
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sparser
"A11 Agonist or Antagonist A1 AII AIII SARILE DUP-753 PD-123319 Inhibition of Binding; IC,, (nM) Clone 9 Clone 9 (24 well) Adrenal Cortex 450 f 150 13.6 2 4.6 472 & 116 11.4 2 3.7 19.2 2 5.3 z 10,Ooo' 61, 642 2.8, 1.2 90,so N-P NT NT 210,430 9.4, 7.8 15, 30 3.2, 3.4 24,74 NT 1036 0 KOZLOWSKI,ARCURI, AND ZYNARDI mL I Z 80 100 1 10 100 CONCENTRATION (nu) 1000 Figure 2."
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