IndraLab

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USP13 activates USP13. 9 / 10
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"Inhibition of the phosphorylation of USP13 downregulated USP13 protein stability and reduced the proliferation of ovarian cancer cells, which may lead to novel therapeutics targeting USP13 in USP13-amplified cancers."
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"Phosphorylation of USP13 at Thr122 by CK2 increases the stability of USP13, which in turn promotes ovarian cancer proliferation."
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"( D ) Hypoxia increased USP13 , TLR4 , MyD88 , and P-NF-kappaB p65 proteins , which was subsequently reduced by USP13 knockdown ."
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"This study revealed that USP13 is phosphorylated at Thr122, which upregulates the stability of USP13 at a post-translation level."
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"Overexpression of USP13 in PC12 cells almost reversed the Spautin‐1‐mediated decrease in NLRP3, USP13, Beclin1 and GSDMD‐N expression levels (Figure 3D,E)."
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"We further demonstrated that Casein kinase 2 (CK2) directly interacts with and phosphorylates USP13 at Thr122, which promotes the stability of USP13 protein."
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"Moreover, low USP13-expressing HOS cells were chosen to overexpress USP13 stably (Fig. S2a)."
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"Genes most strongly decreased in ALS included MAP kinase activating death domain (MADD) and ubiquitin specific peptidase 13 (USP13) (Figures 2H–N)."
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"CK2 phosphorylates the Thr122 residue of USP13, which upregulates the stability of USP13 at a post-translation level."
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