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USP3 decreases the amount of MYCN. 2 / 2
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"Further studies revealed that in vitro experiments and in vivo transgenic models of NBL displayed the formation of a nuclear co-activator complex between ALYREF and MYCN that stimulates the transcript[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As shown in Figure S7, ablation of CCNB1IP1 partially prevented the upregulation of MYCN protein level in Trim32 or Huwe1 knockdown cells, and overexpression of CCNB1IP1 differentially attenuated the downregulation of MYCN protein level caused by USP3 or USP5 silencing."
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