IndraLab

Statements


A-935142 activates KCNH2. 3 / 3
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"In conclusion, A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization."

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"In a previous study we found that A-935142 enhanced hERG current in a concentration dependent manner by facilitating activation, reducing inactivation, and slowing deactivation (Su et al., 2009)."

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"A-935142 shortened cardiac action potentials and enhanced the amplitude of the hERG current in a concentration- and voltage dependent manner."