IndraLab

Statements

OTUB1 deubiquitinates NR4A1. 5 / 5
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"We found that <span class="match term0">OTUB1</span> interacted with <span class="match term1">Nur77</span> to deubiquitinate it, thereby stabilizing <span class="match term1">Nur77</span> in an Asp88-dependent manner. "
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"OTUB1 significantly reduced Nur77 polyubiquitination, whereas knockout of OTUB1 potentiated Nur77 polyubiquitination ( Fig. 2 D & E)."
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"These results confirmed that OTUB1 reverses K48-linked ubiquitination of Nur77.We examined whether the deubiquitination of Nur77 by OTUB1 was dependent on its catalytic activity."
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"To demonstrate that OTUB1 was indeed able to deubiquitinates Nur77 and thereby antagonizes Trim13, we performed a Nur77 stability and ubiquitination assay as well as a CHX chase assay."
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"OTUB1 not only promoted the deubiquitination of Nur77 but also Trim13."
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