IndraLab

Statements

USP30 inhibits PEX2. 3 / 3
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"The deubiquitinating enzyme ubiquitin-specific protease 30 (USP30) can inhibit pexophagy by antagonizing PEX2, thus maintaining the balance of the number of peroxisomes in cells [63]."
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"Overexpression of USP30 prevents pexophagy during amino acid starvation, by counteracting the action of the peroxisomal E3 ubiquitin ligase PEX2 XREF_BIBR, XREF_BIBR."
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"In addition, co-depletion of PEX2 resulted in an abolishment of the peroxisome loss seen in USP30 depleted cells, suggesting that USP30 acts in opposition to PEX2 and is required to keep basal pexophagy to a minimum."
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