IndraLab

Statements

BAP1 decreases the amount of PROS1. 3 / 3
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"Kaler et al. found that BAP1 deficiency leads to increased PROS1 expression in melanoma cells, polarizes macrophages toward the M2 state, activates the suppressive tumor immune microenvironment, and ultimately promotes immune escape [29]."
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"These findings suggest that BAP1 represses PROS1 at least in part by epigenetic mechanisms, and that BAP1 loss leads to increased PROS1 expression."
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"Here, we show that BAP1 loss leads to increased expression of PROS1 in uveal melanocytes and melanoma cells, which in turn leads to phosphorylation and activation of the receptor tyrosine kinase MERTK on adjacent macrophages, driving them into a suppressive M2-polarized state."
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