IndraLab

Statements

Curcumin inhibits CASP1. 9 / 9
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"Yin et al. showed that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing lipopolysaccharide ( LPS ) priming and NLRP3 inflammasome in mouse bone marrow-derived macrophages , and confirmed these results in vivo in a model of high-fat diet-induced insulin resistance in wild-type C57BL / 6 mice [ 72 ] ."
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"As a result from suppression of ER stress associated TXNIP induction, curcumin inhibited NLRP3 and caspase-1 activation, and thereby reduced IL-1beta secretion."
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"Since inflammation is one of the important pathological mechanisms of hypoxia injury, curcumin may inhibit the activation of caspase-1 by inhibiting NLRP3 inflammasome, thereby reducing the maturation and release of IL-1, reducing the proliferation of inflammation-induced PASMCs, improving the remodeling of blood vessels, and ultimately reducing pulmonary artery pressure in PHA rats."
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"In the IP experiments, repeated treatment with 120 mg/kg curcumin reversed the increased aggregation of ASC, NALP1, and caspase-1 within the NALP1 inflammasome complex (Fig. 4E)."
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"Here, we discovered that Curcuma phaeocaulis can suppress caspase-1 activation and processing of pro-IL-1β into mature cytokine in macrophages stimulated with NLRP3 inflammasome activators, such as SiO 2 or TiO 2 nanoparticles."
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"Silencing of NLRP3 or ASC by siRNA did not inhibit curcumin induced caspase-1 activation in mouse MM cells."
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"We report that curcumin inhibited caspase-1 activation and IL-1beta secretion through suppressing LPS priming and the inflammasome activation pathway in mouse bone marrow derived macrophages."
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"In diabetic mice, the Nrf2 inducer curcumin decreased NLRP3 inflammasome activity, as reported by reduced protein levels of IL-1beta, cleaved caspase-1, and NLRP3 [XREF_BIBR]."
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"Curcumin suppressed the upregulation of NLRP3, caspase-1, pro-IL-1beta and IL-1beta proteins (XREF_FIG), the increased ratio of caspase-1 to procaspase-1 and IL-1beta to pro-IL-1beta (XREF_FIG), as well as the enhanced caspase-1 activity (XREF_SUPPLEMENTARY), but had no significant effect on procaspase-1 expression (XREF_FIG) in SHR derived VSMCs."
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