IndraLab

Statements

DHB activates KCNH2. 5 / 5
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"These findings demonstrated that the hERG trafficking defect induced by DHB activates UPR."
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"DHB accelerates hERG channel inactivation."
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"Together, our findings shed light on the potential mechanisms of the DHB induced hERG channel deficiency which may provide a better understanding of drug induced LQTS."
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"HEK293 cells transiently transfected with hERG cDNA was used to identify the binding sites that induce the acute inhibition of hERG channel triggered by immediate DHB perfusion."
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"These findings suggested that DHB induced hERG trafficking defect results from protein misfolding, which may due to the reduction of Hsp90 expression and the aberrant interaction between hERG protein and molecular chaperones."
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