IndraLab

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USP12 binds PHLPP1. 13 / 14
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"We demonstrated that Usp12, and two Usp12 interacting proteins, Uaf-1 and WDR20 [XREF_BIBR], [XREF_BIBR], form a complex with PHLPP and PHLPPL."
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"Additionally, Usp12 was predicted to interact with both of these phosphatases and a more recent report confirmed the interaction between Usp12 and PHLPP in colorectal cells [XREF_BIBR]."
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"Interestingly, we observed that PHLPP1 specifically associated with WDR48 and USP12 but not other USPs (XREF_FIG C)."
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"Additionally, Usp12 was predicted to interact with both of these phosphatases and a more recent report confirmed the interaction between Usp12 and PHLPP in colorectal cells [ xref ]."
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"In agreement with the previous study, we found that both PHLPP and PHLPPL interacted with Usp12."
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"In CRC, a mutation in the protein WD repeat domain 48, required for interaction between PHLPP1 and USP12, resulted in PHLPP1 downregulation and consequent increase in AKT signaling ( Gangula and Maddi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Here we report that Usp12, in complex with Uaf-1 and WDR20, interacts with PHLPP and PHLPPL in PC cells resulting in their deubiquitination and protein stabilisation."
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No evidence text available
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"In CRC, a mutation in the protein WD repeat domain 48, required for interaction between PHLPP1 and USP12, resulted in PHLPP1 downregulation and consequent increase in AKT signaling (Gangula and Maddik[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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No evidence text available
27880917