IndraLab

Statements

OTUD7B activates osimertinib. 6 / 6
| 6
reach
"Cezanne was highly expressed in Osimertinib-resistant cells, and Cezanne overexpression promoted Osimertinib resistance, while chloroquine (CQ), an autophagy inhibitor, reverted this process."
37596251
reach
"The IC50 assay also proved the resistance of Osimertinib induced by Cezanne and the addition of CQ significantly decreased the Osimertinib resistance in LUAD cell lines, PC9 and HCC827 cells (Fig. 1F, G), which suggested Cezanne promoted Osimertinib resistance and autophagy played a vital role (Fig. 8)."
37596251
reach
"To investigate the connection between Cezanne and Osimertinib resistance in LUAD, analysis of the expression of Cezanne using the GEO data was conducted, which showed that Cezanne expression elevated in the Osimertinib-treated PC9 cells (Fig. 1A) and Osimertinib-resistant HCC827, H1975 cells (Fig. 1B, C)."
37596251
reach
"As shown in Fig. 1D and E, Cezanne knockdown with siRNA decreased Osimertinib sensitivity in PC9 and HCC827 cells, while Cezanne-Overexpressing (Cezanne OE) cells developed Osimertinib resistance (Fig. 1F, G)."
37596251
reach
"Therefore, our results suggested that Cezanne contributed to Osimertinib resistance in LUAD cells.Autophagy activation is related to Osimertinib resistance in several types of tumors [6], and our study indicated that the autophagy inhibitor CQ could inhibit the Osimertinib resistance induced by Cezanne (Fig. 1F, G), which suggested Cezanne promoted Osimertinib resistance in an autophagy-dependent way."
37596251
reach
"Cezanne promoted Osimertinib resistance by accelerating EGFR recycling."
37596251