IndraLab

Statements

CYLD activates AP1. 4 / 4
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reach
"We found that CYLD m increased AP1 driven expression both in the presence and absence of EGF; whereas CYLD WT reduced AP1 activity in both conditions (XREF_FIG)."
21478324
sparser
"Thus, the exact mechanism of MALT1- and CYLD-dependent AP-1 activation and the role of JNK in this pathway remain to be further explored."
26507244
reach
"CYLD Inhibits Tumorigenesis and Metastasis by Blocking JNK and AP1 Signaling at Multiple Levels."
21478324
reach
"In addition, CYLD WT markedly reduced while CYLD m significantly potentiated AP1 activity driven by exogenous c-Fos expression; conversely, gene silencing of c-Jun or c-Fos abolished AP1-induction by CYLD m (XREF_FIG)."
21478324