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USP4 inhibits myoblast differentiation. 4 / 4
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"To test this hypothesis, we evaluated the effect of USP4 on myoblast differentiation in C2C12 cells, a mouse myoblast cell line, and confirmed that a USP4 knockdown promotes myoblast differentiation."
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"These results showed that USP4 suppresses myoblast differentiation by inhibiting the p38 signaling pathway.The ubiquitin proteasome system plays a critical role in muscle differentiation by controllin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus the effect of USP4 on myogenesis is independent of the catalytic activity of USP4.It is known that HDAC1 directly binds to MyoD for the inhibition of myogenic differentiation and that the inhibit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Considering current results and previous known mechanism of USP, it can be hypothesized that USP4 is likely to regulate the function of key signaling proteins in myogenesis via protein-protein interac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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