IndraLab

Statements


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"USP26 binds to CBX4 and CBX6 in RING1A independent manner."

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"ChIP-qPCR of the promoters of Sox2, Nanog, Oct4, and Cbx7 in Usp26 differentiated ESCs on day 6 revealed binding of USP26, CBX4, CBX6, H2A-ubi1, and H3K27me3 to the Sox2, Nanog, and Cbx7 promoters, suggesting that promoter binding of these components led to a decrease in pluripotency gene expression."

No evidence text available

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"To determine whether USP26 interacts with the PRC1 components RING1A, CBX4, and CBX6 independent of each other, we generated RING1A, CBX4, or CBX6 knockout 293T cells using CRISPR and Cas9 technology."

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"Since the undifferentiated ESCs expressed CBX7 but no USP26, endogenous interactions between USP26 and CBX4 or CBX6, but not CBX7, were only observed in differentiating ESCs."

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"However, when USP26 was expressed with either Cbx4 or CBX6, significantly decreased promoter activities of Sox2, Nanog, and Cbx7 were observed, suggesting that USP26 interacts with Cbx4 or Cbx6 alone or both in Cbx7 promoter for CBX7 suppression."