IndraLab

Statements

USP9X increases the amount of USP9X. 13 / 13
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"The protein levels of USP9X and Nrf2 were elevated by USP9X overexpression, yet diminished by USP9X silencing (Figure 2(F–H), p < 0.05)."
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"Western blotting showed that USP9X overexpression increased USP9X protein level, and USP9X knockdown decreased USP9X protein level in Z-138 and Jeko-1 (Figure 2A)."
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"Both USP9X siRNAs markedly reduced USP9X protein levels after 48 h transfection, and also resulted in decreased TTK levels (Figure 2C)."
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"LPS promoted the expression of Usp9x and TLR4, while Usp9x silencing inhibited the expression of Usp9x and TLR4 (Figure 3A)."
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"Second, inducible USP9X specific shRNA mediated knock-down, and transient over-expression of full length USP9X resulted in a concomitant decrease and increase in RAPTOR protein, respectively."
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"USP9X has been shown to regulate multiple cellular functions, and increased expression of USP9X in tumors is significantly associated with poor prognosis for patients with multiple myeloma [XREF_BIBR]."
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"Usp9x knock-in mice expressing the fusion protein tdTomato-T2A-Usp9X allowed a more detailed analysis of Usp9x mRNA expression in the hematopoietic compartment (XREF_FIG)."
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"However, SOX11 overexpression in USP9X knockdown MCL cells suppressed SOX11 overexpression-mediated USP9X and SOX11 protein levels (Figure 6A)."
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"An early study found that the USP9x protein expression in prefrontal cortex increases after 21-day withdrawal from repeated non-contingent cocaine administration in rats (Xu et al., 2010), which is in line with our data here showing increased Usp9x mRNA expression in DS neurons after prolonged abstinence from Meth self-administration."
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"IHC showed that USP9X knockdown increased TUNEL expression and decreased Ki67, USP9X, CCND1, and SOX11 expression in tumor tissues (Figure 7C)."
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"Western blotting demonstrated that USP9X knockdown decreased USP9X protein level, and SOX11 overexpression showed no effect on USP9X protein level in MCL cells."
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"USP9X knockdown reduced tumor volume and weight, inhibited TUNEL expression, and repressed Ki67, USP9X, CCND1, and SOX11 expression in tumor tissues."
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"After transfection, USP9X overexpression notably up-regulated USP9X mRNA level, while USP9X silencing did the opposite (Figure 2(E), p < 0.001)."
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