IndraLab

Statements

1b-2 decreases the amount of HCN1. 2 / 2
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"Specifically, TRIP8b (1a-4) increases HCN1 surface expression (Zolles et al., 2009), whereas TRIP8b (1b-2) inhibits the transport of HCN1 channel from the plasma membrane (Biel et al., 2009), thereby strongly downregulating HCN1 expression on the cell membrane."
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"Thus, the decreased ability of TRIP8b (1b-2) to abolish HCN1 surface expression seen with truncation of the channel 's SNL tripeptide is rescued upon truncation of the entire non conserved C-terminus of HCN1 (XREF_FIG)."
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