IndraLab

Statements

Ethanol inhibits CTSL. 5 / 5
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"Whereas ethyl alcohol suppressed the pseudohyphal defects of Mep 2, Gpa 2 and Gpr 1 strains of S. cerevisiae which are the regulator of the MAPK network."
33628606
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"Ethanol administration appeared to disrupt cathepsin L processing at an early step, since only the ratios of the 39 kDa cathepsin L proform to its intermediate (30 kDa) and final (25 kDa) products wer[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8781524
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"Chronic ethanol feeding is associated with decreased intralysosomal hydrolases content and reduced proteasomal activity due to impaired cathepsin L trafficking in the lysosome [XREF_BIBR, XREF_BIBR]."
26788252
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"These results suggest that while ethanol ingestion significantly impaired the processing of the cathepsin L proform, it did not affect the step required for conversion of its intermedi- ate form to th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8781524
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"The latter findings suggest that ethanol blocks the maturation of cathepsin L, altering its trafficking enroute to lysosomes."
8541322