IndraLab

Statements


TNFSF11 increases the amount of CYLD. 3 / 3
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"32 In mouse bone marrow derived macrophages, CYLD expression is strongly induced by RANKL, but not by TNF-alpha or LPS."

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"40 RANKL stimulated osteoclastogenesis potently induces the expression of CYLD, and the accumulated CYLD targets TRAF6 by interacting with the adaptor protein, p62."

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"Furthermore, MG132 treatment extended the half-life of endogenous CYLD protein following RANKL stimulation in RAW264.7 mouse macrophage cells, as RANKL stimulation induces CYLD mRNA expression, thereby bypassing the down-regulation of CYLD mRNA expression by MG132."