IndraLab

Statements


U0126 inhibits STAT1. 6 / 6
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"U0126 dramatically abolished the Stat1 activation in both WT- and Spred2 -splenocytes (Fig. 4E)."

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"MEK inhibitor U0126 inhibits viral gene expression [XREF_BIBR] as well as the activation of host c-Fos, c-Jun, c-Myc, and STAT1 molecules."

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"Interestingly, U0126 treatment of Spred2 mice significantly decreased Stat1 activation in Spred2 -livers relative to the controls (Fig. 3C)."

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"As shown in XREF_FIG, levels of FOS, MSK1, STAT1 and STAT3 were significantly reduced in decidualized hESCs treated with U0126."

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"As shown in Figure XREF_FIG, both DPI and U0126 reduced the nuclear accumulation of JunB, c-Jun, and HIF-1alpha, but not Stat1 (which is DUOX2 independent) or Sp1 (which is constitutively expressed)."

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"Compared with the untreated controls, Dip G markedly promoted the nuclear translocation of p-STAT1 (Ser727), which was blocked by U0126 (XREF_FIG)."