IndraLab

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Ubiquitinated TP53 decreases the amount of TP53. 5 / 5
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"Almac4 treatment and USP7 depletion led to decreased USP7, MDM2, N-myc, and EZH2 expression levels and to increased p53 expression, with reduced p53 ubiquitination and increased EZH2 ubiquitination (Figure 9)."
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"Additionally, in cells infected with human papilloma virus (HPV), the viral E6 protein promotes the binding of p53 to the E3-ligase E6AP, which in turn ubiquitinates p53 efficiently and severely reduces cellular p53 protein levels."
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"On the other side, the ubiquitinated TP53 could be reversed and stabilized by USP7 and USP10, to keep the amount of TP53 in check."
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"These reports indicate that p53 ubiquitination negatively regulates both p53 transcription-dependent and -independent cell death."
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"Compared with the EGFP control, overexpression of either RSL1D1-NT or RSL1D1-CT significantly increased the levels of p53 protein (Fig. 7E) by inhibition of p53 ubiquitination (Fig. 7F) in HCT116 cells, consistent with the increased level of p53 protein (Fig. 2B) and decreased p53 ubiquitination (Fig. 3A) in RSL1D1-downregulated cells."
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