IndraLab

Statements

USP22 activates transcription, DNA-templated. 5 / 5
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"Transcriptionally, USP22 leads to H2BK120Ub on chromatins among the FOXP3 locus to enhance its transcription."
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"At the biochemical level, these Polycomb proteins function as global transcriptional repressors by catalyzing the ubiquitylation of histone H2A. In yeast, the USP22 homolog functions as a transcriptional coactivator by removing ubiquitin from a distinct core histones, H2B. Given that USP22 is expressed in cancer as part of an 11 gene signature that includes transcriptional repressors which ubiquitylate H2A, it seemed possible that USP22 might activate transcription in part via the deubiquitylation of this same substrate."
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"USP22 positively regulated transcription factor FOXP3 activity in mouse regulatory T (T reg) cells."
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"In addition, USP22 binds to the promoter region of AP4 to activate its transcription."
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"USP22 positively regulated transcription factor FOXP3 activity in mouse regulatory T (T reg) cells."
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