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USP22 activates DNA-templated transcription. 9 / 9
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"Taken together, these results suggest that USP22 silencing inhibits the inflammatory response and lipid accumulation in ALD.BRD4 can bind to acetylated histones and transcription factors through its b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, USP22 binds to the promoter region of AP4 to activate its transcription."
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"USP22 positively regulated transcription factor FOXP3 activity in mouse regulatory T (T reg) cells."
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"Consistently two of its complex partners, ATXN7L3 and ENY2, are required for optimal USP22-mediated transcription activation by nuclear receptors in vivo [67] ."
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"Moreover, SOX9 was also reported to bind the promoter of ubiquitin-specific peptidase 22 (USP22), a deubiquitinating enzyme, promote its transcription, and activate the Wnt/β-catenin pathway (Miao et al., 2022)."
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"At the biochemical level, these Polycomb proteins function as global transcriptional repressors by catalyzing the ubiquitylation of histone H2A. In yeast, the USP22 homolog functions as a transcriptional coactivator by removing ubiquitin from a distinct core histones, H2B. Given that USP22 is expressed in cancer as part of an 11 gene signature that includes transcriptional repressors which ubiquitylate H2A, it seemed possible that USP22 might activate transcription in part via the deubiquitylation of this same substrate."
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"USP22 overexpression enhances colon cancer migration and invasiveness by inducing EMT via activating AP4 (activating enhancer binding protein-4) transcription by binding to its promoter[54]."
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"Transcriptionally, USP22 leads to H2BK120Ub on chromatins among the FOXP3 locus to enhance its transcription."
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"USP22 positively regulated transcription factor FOXP3 activity in mouse regulatory T (T reg) cells."
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