IndraLab

Statements

USP7 activates SUV39H1. 4 / 4
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"Finally, we transiently overexpressed USP7 in HCT116 p53 -/- cells, treated with cycloheximide to block new protein synthesis and observed a significant increase in SUV39H1 half-life (XREF_FIG), confirming that USP7 positively regulates SUV39H1 protein stability."
26971997
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"These results argue that functional USP7 is required to maintain SUV39H1 dependent H3K9me3 enrichment on p53 target promoters.Next, we sought to determine the functional significance of USP7 mediated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26971997
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"By either mechanism, our results establish that USP7 modulates the repressive H3K9me3 mark by protecting SUV39H1 from MDM2 mediated degradation and blocking aberrant p53 transactivation of target genes in unstressed p53 wt cells."
26971997
reach
"USP7 enhances SUV39H1 stability, independent of p53."
26971997