IndraLab

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COPS5 activates Cyclin_E. 4 / 5
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"For example, Doronkin et al. demonstrated that depletion of Jab1 and COPS5 induced cyclin E stability whereas Jab1 and COPS5 overexpression rapidly degraded cyclin E."
29535627
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"Our results show that the CSN regulates the turnover of Cyclin E. Decreased expression of CSN5 increased Cyclin E stability, and increased CSN5 expression stimulated rapid Cyclin E degradation."
12737805
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"Also, authors reported that decreased Jab1 and CSN5 expression increased cyclin E stability and that increased Jab1 and CSN5 expression stimulated rapid cyclin E degradation [XREF_BIBR]."
22867945
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"We conclude that CSN5 stimulates Cyclin E degradation.We also overexpressed Cyclin E in wild-type flies to determine its effects on oogenesis when the CSN was not mutant."
12737805