IndraLab

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BAP1 inhibits Lymphoma, B-Cell. 3 / 3
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"To further determine how loss of BAP1 accelerates B cell lymphoma cells growth in vivo via regulating immune cell infiltration and TME, we conducted single-cell RNA-Seq (scRNA-seq) with the tumor samples from both BAP1-WT and -KO tissues (Supplemental Figure 5A)."
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"However, the loss of BAP1 leads to a substantial acceleration of B cell lymphoma cell growth in immunocompetent mice, indicating that BAP1 may function as a tumor suppressor via regulating TME and tumor immune response in this context.Decrease or loss of MHC-II expression in B cell lymphoma has been associated with genetic alterations, such as CIITA deficiency, and is associated with poor survival in human B cell lymphoma."
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"In our current studies, we demonstrated that PRC1 is responsible for the transcriptional repression of MHC-II genes upon BAP1 depletion, as inhibition of PRC1 could largely rescue the gene-expression defect in BAP1-depleted B cell lymphoma cells."
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