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Melatonin inhibits NLRP3. 91 / 91
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"Incidentally, in COVID-19, pyroptosis gives rise to exaggerated inflammation and melatonin can block pyroptosis by antagonizing NF-κB and NLRP3 signaling [33], [34]."
| PMC
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"Moreover, oxidative stress and NLRP3 inflammasome activation in carotid arteries of smoking rats was also inhibited by melatonin."
31521245
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"Moreover, melatonin has been described as an endoplasmic reticulum stress mediator, promoting TRX1 activity by inhibiting the TXINP and NLRP3 pathway [XREF_BIBR]."
33321938
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"In this study, melatonin was observed to inhibit ROS production, NLRP3 inflammasome activation and pyroptosis in CSE treated ECs."
31521245
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"In ox-LDL-treated macrophages, melatonin attenuated the NLRP3 inflammasome activation and the inflammatory factors secretion, while this protective effect was abolished by either Sirt3 silence or autophagy inhibitor 3-MA."
30254716
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"Likewise, via SIRT1 stimulation, melatonin inhibits the NLRP3 inflammasome and IL- 1β generation."
| PMC
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"Melatonin reduced NLRP3 , caspase-1 and ASC speck formation ."
31327964
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"Melatonin inhibits NLRP3 inflammasome and pyroptosis with diminished cas-pase1, IL-1βand IL 18 production and suppressive NF-κB activation."
35356091
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"Previous in vitro and in vivo studies established that melatonin suppresses the NLRP3 inflammasome mainly by inhibition of NF-κB signaling, activation of SIRT1 and Nrf2 pathways, and inhibition of ROS production."
34202842
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"Of note, we have revealed that radiation induced NLRP3 inflammasome activation was attenuated by melatonin exposure, while this effect of melatonin was markedly negated by repressing miR-30e levels with its inhibitor in macrophages."
30755784
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"In conclusion, our data demonstrated that melatonin attenuates neuroinflammation by negatively regulating NLRP3 inflammasome activation via a SIRT1 dependent pathway in MPTP induced PD models."
34267535
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"* Melatonin : Melatonin has been shown to inhibit NFkB activation and NLRP3 inflammasome activation."
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"Melatonin also significantly reduced the oxidative stress and injury of lungs exposed to radiation through the suppression in the infiltration of neutrophils (CD11b+Ly6G+) and macrophages (CD11b+CD11c-), and the down-regulation of NLRP3 inflammasome in macrophages (accompanied with a reduction in the release of IL-1β and the activity of caspase-1 or CASP1), by the up-regulation of miR-30e levels [79]."
32422305
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"Specifically, in rats with COPD, melatonin can inhibit the NLRP3 inflammasome and IL-1β, thus alleviating airway inflammation [62], suggesting that melatonin can delay the onset and development of COPD by acting against inflammation."
34733115
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"Additionally, the results showed that melatonin suppressed NLRP3 inflammasome activation by regulating Wnt and beta-catenin signaling, which was confirmed by the Wnt and beta-catenin inhibitor recombinant DKK1."
29804160
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"Similar results were achieved in vivo where in wild-type mice , melatonin reverted cognitive decline , reduced NLRP3 levels , and increased autophagic degradation ."
35326182
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"Melatonin has been reported to inhibit the activation of NLRP3 inflammasome in various diseases including atherosclerosis, sepsis, and also CNS diseases [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
33777317
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"Melatonin may reduce NLRP3 inflammasome activation by inhibiting oxidative stress and thus protect against injury from AFB1 induced myocardial toxicity."
33081548
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"Furthermore , melatonin reduced expression of NLRP3 , ASC , cleaved caspase-1 , GSDMD , and cleaved GSDMD , and decreased the number of Iba1 / IL-1beta-positive cells ."
36031799
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"It is known that melatonin prevents the activation of NLRP3 inflammasome."
33848919
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"Moreover, exogenous melatonin pronouncedly ameliorated airway inflammation and decreased the activation of NLRP3 inflammasome."
31738882
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"Garcia et al. reported that melatonin inhibits NF-kappaB and NLRP3 activation by regulating the retinoic acid receptor related orphan receptor alpha pathway [XREF_BIBR]."
32377306
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"And colleagues found that melatonin could inactivate NF-kappaB induction , reduce NLRP3 expression and alleviate the inflammatory state of sepsis ( 77 ) ."
34305952
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"Many in vitro and in vivo studies have shown that MT inhibits NLRP3 inflammasome activity via various intracellular signaling pathways (Ehirli et al., 2021)."
34737710
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"Melatonin has been shown to inhibit NLRP3 (nucleotide-binding oligomerization domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome activation under various conditions [47]."
| PMC
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"In vivo , melatonin reverted LPS-induced cognitive decline , reduced NLRP3 levels and promoted autophagic flux in the hippocampi of WT mice , whereas in alpha7 nAChR KO mice melatonin effect was not observed ."
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"Notably, oxLDL leads to inflammasome activation and pro inflammatory factor secretion, and melatonin treatment significantly reduced the production of NLRP3 inflammasome and IL-1beta secretion in oxLDL treated macrophages [XREF_BIBR]."
33557283
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"Melatonin lowered NLRP3 protein to sham levels in WT mice, while in alpha7 nAChRs KO melatonin treated animals had significantly elevated NLRP3 expression compared to melatonin treated WT group (XREF_FIG D)."
33353046
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"Preceding studies reported that sirtuins attenuate NLRP3 inflammasome activation by deacetylating of NLRP3 protein [63], and melatonin increased SIRT1 activity to inhibit the NLRP3 inflammasome [62,64]."
34202842
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"Melatonin suppresses NLRP3 inflammasomes, proinflammatory cytokine activation and facilitates switching of highly inflammatory M1 macrophages to anti-inflammatory M2 macrophages ([[23], [24]], [25] In numerous animal viral diseases it has been shown to greatly enhance survival."
| PMC
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"Besides, a recent study has shown that the antiinflammatory drug melatonin inhibits NF-kB cascades and NLRP3 inflammasome, the two main pathways during SARS-CoV-2 infection."
34650550
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"The results indicated that melatonin could attenuate prostate inflammation and pelvic pain by inhibiting the NLRP3 inflammasomes signaling pathway through the activation of Sirt1 in mice with EAP, and these efforts should provide a promising therapeutic strategy for CP/CPPS."
34418127
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"Besides, a recent study has shown that the anti-inflammatory drug melatonin inhibits NF-κB cascades and NLRP3 inflammasome, the two main pathways during SARS-CoV-2 infection."
34650550
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"Melatonin prevents activation of NLRP3 in myocardial tissue exposed to AFB1."
33081548
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"Nevertheless , the downregulation of NLRP3 by melatonin through ROS scavenging seems to be involved in more researches ."
33777317
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"However, it is not clear whether MT plays a role in regulating the innate and adaptive immune responses during corneal graft rejection.Our study aimed to further demonstrate that MT inhibits NLRP3 in a corneal transplantation model, thereby affecting the migration of both innate and adaptive immune cells to the corneal and cervical lymph nodes, as well as the secretion of inflammatory factors and chemokines, thereby modulating the immune response to promote rejection after transplantation.Female C57BL/6 and BALB/c mice (6–8 weeks of age) were used in this study."
34737710
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"Furthermore, melatonin decreased NLRP3 inflammasome activation and the consequent IL-1 beta secretion within atherosclerotic lesions."
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"Our study aimed to further demonstrate that MT inhibits NLRP3 in a corneal transplantation model, thereby affecting the migration of both innate and adaptive immune cells to the corneal and cervical lymph nodes, as well as the secretion of inflammatory factors and chemokines, thereby modulating the immune response to promote rejection after transplantation."
34737710
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"CRIDs/MCC950 and melatonin inhibits the NLRP3 components of the inflammasome, while melatonin additionally inhibits the production of ROS which contributes to inflammsome activation."
| PMC
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"Melatonin also attenuated NLRP3 inflammasome activation and pyroptosis, which was induced by LPS or obesity."
28398673
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"In addition, melatonin was found to inhibit the development of the NLRP3 inflammasome by suppressing extracellular histone release."
33576451
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"Melatonin suppresses NLRP3 inflammasomes, proinflammatory cytokine activation and facilitates switching of highly inflammatory M1 macrophages to anti-inflammatory M2 macrophages ([XREF_BIBR, XREF_BIBR], [XREF_BIBR] In numerous animal viral diseases it has been shown to greatly enhance survival."
| PMC
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"Moreover, melatonin suppresses NLRP3 inflammasome activation induced by cigarette smoking and attenuates pulmonary inflammation [XREF_BIBR], not only via reduction of NF-kappaB p65 and tumor necrosis factor-alpha (TNF-alpha) expression, but also via increase in anti-inflammatory cytokines such as IL-10 or IL-6, which can also have anti-inflammatory effects [XREF_BIBR, XREF_BIBR]."
33156843
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"Melatonin interacted with this pathway to inhibit the NLRP3 inflammasome through SIRT-1 and the modulation of micro-RNA expressions 41."
34773065
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"Neurological benefit of NLRP3 inflammasome attenuation by melatonin was also found in LPS induced acute depressive like behaviors."
33777317
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"Moreover, melatonin effectively reduced NLRP3 inflammasome triggering in RLE-6TN cells."
35109747
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"When human nucleus pulposus (NP) cells from IVDD patients are subjected to IL-1β, NLRP3 inflammasome is activated, while melatonin co-treatment prevents this activation and downregulates NLRP3 inflammasome components via suppression of NF-κB activity and mitochondrial ROS production [144]."
34202842
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"Melatonin attenuates the expression of pyroptosis‐related genes, including NLRP3, ASC, cleaved‐caspase‐1, GSDMD, IL‐1β and IL‐18, in aortic endothelium."
30525268
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"Moreover, in the irradiated RAW 264.7 cells, melatonin blocked the NLRP3 inflammasome activation accompanied with the inhibition of the IL-1beta release and caspase-1 activity."
30755784
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"Herein, we demonstrate that melatonin suppressed prolonged NLRP3 inflammasome activation in atherosclerotic lesions by reactive oxygen species (ROS) scavenging via mitophagy in macrophages."
30254716
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"A recent study by our team has shown that melatonin injection inhibits LPS-induced depressive-like behavior in mice by downregulating NLRP3 activation in the brain [64]."
34202842
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"Moreover, MT inhibited the activation of the NF-kappaB pathway, and reduced the expression of inflammation related proteins (iNOS and COX-2), and pyroptosis related proteins (NLRP3, caspase-1, and GSDMD)."
33842634
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"We made the following observations : (1) treatment with melatonin upregulated mitophagy associated proteins (PINK1 and Parkin) and reduced mitochondrial damage and ROS generation after SAH; (2) administration of melatonin inhibited NLRP3 inflammasome activation after SAH and attenuated the inflammatory response; (3) melatonin treatment reduced neuronal cell death, brain edema and neurological dysfunction following SAH; and (4) pretreatment with 3-MA reversed the beneficial effect of melatonin on the inhibition of NLRP3 inflammasome activation."
28546552
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"Melatonin obviously decreased both NLRP3 and consequential caspase-1 activation , indicating that melatonin reduced ox-LDL-induced NLRP3 inflammasome activation ."
30254716
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"Indeed, a great many studies in cells cultures or rodents have shown that melatonin can suppress the activation of NLRP3 inflammasomes [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
33375692
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"In many studies, melatonin was indicated to attenuate NLRP3 inflammasome due to its anti-inflammatory, antioxidative, and immunomodulatory effects [14,131]."
34202842
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"Melatonin inhibited NLRP3 inflammasome activation and attenuated pro inflammatory cytokine secretion after SAH."
28546552
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"Melatonin Reduces NLRP3 Inflammasome Activation by Increasing alpha7 nAChR Mediated Autophagic Flux."
33353046
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"Furthermore, melatonin inhibited the NLRP3 inflammasome activation through the suppression of extracellular histone release [XREF_BIBR]."
32422305
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"They have extensively demonstrated that melatonin could inhibit the NLRP3 inflammasome pathway in radiation induced oral mucositis [XREF_BIBR] and cecal ligation induced sepsis [XREF_BIBR]."
30755784
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"Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice."
32738376
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"Here, we show that melatonin reduces oxidative stress and NLRP3 triggering due to activation of autophagic flux."
33353046
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"Inhibition of NLRP3 by MT prevented from the activation of pro-L-1beta and pro-IL-18 , thus blocking the initiation of proinflammatory cytokine cascade [ 82,83,84,85 ] ."
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"In ovalbumin-induced airway inflammation in mice, intraperitoneal (IP) melatonin reduces the NLRP3 activation in lungs."
34202842
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"Further studies await to elucidate it.Based on the above experimental data, we conclude that MT inhibits the activation of NLRP3 inflammasomes to reduce corneal transplant rejection, and that this effect is related to macrophage suppression, T cell regulation, and the reduction in corneal lymphangiogenesis."
34737710
eidos
"Our study aimed to further demonstrate that MT inhibits NLRP3 in a corneal transplantation model , thereby affecting the migration of both innate and adaptive immune cells to the corneal and cervical lymph nodes , as well as the secretion of inflammatory factors and chemokines , thereby modulating the immune response to promote rejection after transplantation ."
34737710
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"Melatonin gel prevents external radiation induced NLRP3 inflammasome pathway activation in small intestine epithelia."
28403142
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"Melatonin inhibits the activation of NLRP3 inflammasome by mediating the Wnt and beta-catenin pathway in BMSCs from ovariectomized (OVX) mice, thereby enhancing osteoporosis in OVX treated mice [XREF_BIBR]."
33215255
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"Melatonin also promotes mitophagy and inhibits NLRP3 inflammasomes in DRG cells."
34398134
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"It has also been detected that melatonin prevents NLRP3 activation during sepsis , thus exhibiting an anti-inflammatory effect ( Fig. 1 ) [ 37 ] ."
33848919
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"Melatonin treatment also inhibits NLRP3 inflammasome activation in oxidized low-density lipoprotein (ox-LDL) treated macrophages via activation of mitophagy."
33816463
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"Melatonin also decreased NF-kappaB-dependent proinflammatory response and restored redox balance and mitochondrial homeostasis, thus inhibiting the NLRP3 inflammasome."
26045547
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"In addition to inhibiting the NF-κB pathway, topical application of melatonin inhibits NLRP3 and mitochondrial dysfunction [57], thereby attenuating inflammatory cytokines."
31597233
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"It is well documented that melatonin prevents chronic obstructive pulmonary disease by attenuating NLRP3 inflammasome and IL-1β, responsible for the inflammation of airways during It was documented that exposure to nicotine in pregnant rats caused significant changes in the lungs of their offspring at a structural and biochemical level."
32422305
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"Glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and NLRP3 inflammasome activation caused by bacterial toxin pyocyanin in colon."
33189867
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"However, it is not clear whether MT plays a role in regulating the innate and adaptive immune responses during corneal graft rejection.Our study aimed to further demonstrate that MT inhibits NLRP3 in a corneal transplantation model, thereby affecting the migration of both innate and adaptive immune cells to the corneal and cervical lymph nodes, as well as the secretion of inflammatory factors and chemokines, thereby modulating the immune response to promote rejection after transplantation."
34737710
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"Nevertheless, the downregulation of NLRP3 by melatonin through ROS scavenging seems to be involved in more researches."
33777317
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"Melatonin can inhibit the hyperactivity of NLRP3 inflammasomes by enhancing mitochondrial autophagy and inhibiting TLR4 and NF-kappaB pathway activity."
33994520
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"62 In this study, we find that melatonin suppresses the activation of several pathways, including mTOR, NF-κB, and NLRP3 inflammasome."
35184395
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"Moreover, in MPP + -primed BV2 cells, melatonin markedly restored the downregulation of SIRT1 and attenuated the activation of the NLRP3 inflammasome."
34267535
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"Findings from the rat SAH model suggest that melatonin inhibits NLRP3 activation by a mitophagy-mediated reduction in ROS [77]."
34202842
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"In in vitro, LPS plus histone stimulated NLRP3 activation model with mouse primary peritoneal macrophages, melatonin prevents-in a dose-dependent manner-the rise in levels of mature, but not pro-forms of IL-1β and caspase-1; indicating that it inhibits the activation but not the priming of the NLRP3 inflammasome [118] ."
34202842
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"Melatonin, by activating the α7nAChR receptor, inhibits the activation of NLRP3 by inhibiting the release of mitochondrial DNA [76]."
34201776
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"Consequently, melatonin mediated upregulation of proteins associated with mitophagy inhibited NLRP3 inflammasome activation and significantly reduced pro inflammatory cytokine levels after SAH."
28546552
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"How melatonin directly blocks activation of the NLRP3 inflammasome in ALI remains unclear."
26888116
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"It was concluded that melatonin can inhibit NLRP3 by regulating non-coding RNAs and has an overall anti-inflammatory effect with the inhibition of inflammatory pathways, such as NFκB, and the activation of mitophagy and the Nrf2/NFE2L2 pathway, diminishing ROS generation."
35326182
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"In mouse model systems, melatonin can inhibit the NLRP3 inflammasome, leading us and others to speculate a role for this inflammatory pathway in COVID-19."
33161818
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"Melatonin could modulate inflammation by decreasing the activation of both NF-kappaB and inflammasomes NLRP3 (nucleotide binding domain leucine rich repeat (NLR) and pyrin domain containing receptor 3)."
32922174
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"It was concluded that melatonin can inhibit NLRP3 by regulating non-coding RNAs and has an overall anti-inflammatory effect with the inhibition of inflammatory pathways , such as NFkappaB , and the activation of mitophagy and the Nrf2 / NFE2L2 pathway , diminishing ROS generation ."
35326182
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"Western blot analysis showed that the expressions of NLRP3 and ASC significantly increased following 15Gy irradiation, whereas melatonin treatment markedly attenuated the NLRP3 and ASC activations compared with those vehicle treated."
30755784
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"It is well documented that melatonin prevents chronic obstructive pulmonary disease by attenuating NLRP3 inflammasome and IL-1β, responsible for the inflammation of airways during this pathology."
32422305