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Melatonin inhibits NLRP3. 187 / 187
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"Nrf2 activation, to help support a healthy inflammatory response, was begun with turmeric (Curcuplex CR, Xymogen), one twice a day, and sulforaphane glucosinolate 100 mg PO BID (Oncoplex ES, Xymogen); low-dose melatonin, ½ tablet of a 3 mg dose (Xymogen, melatonin CR) was used at bedtime to block NLRP3 inflammasomes, a third inflammatory pathway."
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"Melatonin promotes autophagy to inhibit the activation of the mtROS-dependent NLRP3 inflammasome and then decreases the release of IL-1β to exert its anti-inflammatory effect."
37570258
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"When human nucleus pulposus (NP) cells from IVDD patients are subjected to IL-1β, NLRP3 inflammasome is activated, while melatonin co-treatment prevents this activation and downregulates NLRP3 inflammasome components via suppression of NF-κB activity and mitochondrial ROS production [144]."
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"These findings indicated that melatonin may suppress the NLRP3/IL-1β axis and upregulate eNOS expression levels leading to improved vasodilation.Due to the lack of effective treatments available, seps[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Melatonin prevents activation of NLRP3 in myocardial tissue exposed to AFB1."
33081548
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"Majidpoor et al. (2021) found that melatonin decreased the activities of NLRP3, apoptosis associated spotted protein and caspase-1, down regulated the level of IL-1 β and IL-18."
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"Pretreatment with 50 nM of melatonin for 24 hours before treatment of hydrogen peroxide significantly upregulated the expression of nuclear factor-erythroid 2-related factor 2 (Nrf2) transcription factor and downregulated the pyroptosis-related protein NLRP3, cleaved casp-1, and cleaved IL-1β."
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"A previous study suggested that melatonin inhibited the IL-1β-activated NLRP3 inflammasome for inflammatory control [25]."
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"Further studies await to elucidate it.Based on the above experimental data, we conclude that MT inhibits the activation of NLRP3 inflammasomes to reduce corneal transplant rejection, and that this effect is related to macrophage suppression, T cell regulation, and the reduction in corneal lymphangiogenesis."
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"For instance, curcumin or melatonin have been shown to inhibit NLRP3 inflammasome and TLR4/MyD88/NF-κB signaling pathway respectively, reducing abdominal pain as well as acting like immune checkpoints in preclinical models of colitis [3,4,5]."
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"In summary, the results of the experiment indicate that melatonin treatment can reduce the synthesis and release of inflammatory cytokines in BMDMs, inhibit the activation of the NF-κB signaling pathway, and interfere with mitochondrial metabolism, thereby reducing the inflammatory and antibacterial responses.4.3 Melatonin treatment suppresses excessive activation of NLRP3 inflammasome through upregulation of telomerase expression."
38665558
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"This indicates that melatonin treatment can suppress the excessive activation of NLRP3 inflammasome in BMDMs, thereby reducing the synthesis and release of inflammatory cytokines (Fig. 3B & Supplementary fig."
38665558
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"Melatonin inhibits the NLRP3 inflammasome, reducing lung inflammation."
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"Melatonin treatment also inhibits NLRP3 inflammasome activation in oxidized low-density lipoprotein (ox-LDL) treated macrophages via activation of mitophagy."
33816463
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"Melatonin can reduce NLRP3 inflammasome activity, which initiates inflammatory responses and oxidative stress associated with MOR tolerance [64]."
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"62 In this study, we find that melatonin suppresses the activation of several pathways, including mTOR, NF-κB, and NLRP3 inflammasome."
35184395
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"By targeting GSDMD, MT inhibits the activation of NLRP3 inflammasome in adipose tissue of mice and inhibits pyroptosis to alleviate obesity."
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"In our previous study (16), we also found melatonin inhibited NLRP3 inflammasome to relieve apoptosis in DCD hearts."
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"Notably, oxLDL leads to inflammasome activation and pro inflammatory factor secretion, and melatonin treatment significantly reduced the production of NLRP3 inflammasome and IL-1beta secretion in oxLDL treated macrophages [XREF_BIBR]."
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"Moreover, melatonin suppresses NLRP3 inflammasome activation induced by cigarette smoking and attenuates pulmonary inflammation [XREF_BIBR], not only via reduction of NF-kappaB p65 and tumor necrosis factor-alpha (TNF-alpha) expression, but also via increase in anti-inflammatory cytokines such as IL-10 or IL-6, which can also have anti-inflammatory effects [XREF_BIBR, XREF_BIBR]."
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"A study on SCI confirmed that Melatonin inhibited the NLRP3 inflammasome by activating Nrf2/ARE signaling."
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"Zhao revealed that melatonin obviously inhibited the activation of NLRP3 inflammation, ER stress and epithelial-mesenchymal transition during bleomycin-mediated pulmonary fibrosis in mice models (Paxman et al., 2018)."
35559240
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"It is hypothesized that melatonin may prevent the activation of NLRP3 inflammasome, thus protect tissue damage from COVID-19 and periodontitis [180]."
36498871
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"Significantly, melatonin has been found to inhibit the activation of the NLRP3 inflammasome, suggesting that melatonin treatment during COVID-19 or periodontal diseases could alleviate the damage observed in periodontal tissues [59]."
37893162
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"The ability of melatonin to inhibit the activation of the NLRP3 inflammasome adds a promising therapeutic dimension [59]."
37893162
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"Melatonin has been shown to inhibit NLRP3 (nucleotide-binding oligomerization domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome activation under various conditions [47]."
| PMC
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"Additionally, the results showed that melatonin suppressed NLRP3 inflammasome activation by regulating Wnt and beta-catenin signaling, which was confirmed by the Wnt and beta-catenin inhibitor recombinant DKK1."
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"Melatonin suppresses NLRP3 inflammasomes, proinflammatory cytokine activation and facilitates switching of highly inflammatory M1 macrophages to anti-inflammatory M2 macrophages ([XREF_BIBR, XREF_BIBR], [XREF_BIBR] In numerous animal viral diseases it has been shown to greatly enhance survival."
| PMC
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"Zhang et al. found that melatonin can reduce acute lung injury by inhibiting the activation of NLRP3 inflammasomes [18]."
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"In the LPS-induced mouse Depressive-like behavior (DLB) model, Melatonin pretreatment inhibited Keap-1-mediated Nrf2 proteasomal degradation, suppressed NLRP3 inflammasomes activation, downregulated GSDMD cleavage, and ultimately protected N9 microglia from pyroptosis (Arioz et al., 2019)."
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"The key roles of active caspase 1 involve the cleavage of IL-1β, IL-18 and N-GSDMD to induce pyroptotic cell death and excessive levels of cytokines.In conclusion, our research revealed that melatonin could prevent Aβ-induced inflammasome signaling by inhibiting NLRP3, ASC and caspase 1 to induce excessive cytokine release and pyroptosis by decreasing N-GSDMD levels (Fig. 8)."
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"Melatonin can inhibit the hyperactivity of NLRP3 inflammasomes by enhancing mitochondrial autophagy and inhibiting TLR4 and NF-kappaB pathway activity."
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"This indicates that melatonin treatment can reduce the synthesis and release of inflammatory cytokines by inhibiting the excessive activation of NLRP3 inflammasome (Fig. 3C)."
38665558
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"Melatonin gel prevents external radiation induced NLRP3 inflammasome pathway activation in small intestine epithelia."
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"Those results indicate that melatonin can attenuate airway inflammation with COPD by suppressing the NLRP3 inflammasome and IL-1β signaling pathway (Table 1)."
37507744
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"Melatonin also attenuated NLRP3 inflammasome activation and pyroptosis, which was induced by LPS or obesity."
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"Melatonin Reduces NLRP3 Inflammasome Activation by Increasing alpha7 nAChR Mediated Autophagic Flux."
33353046
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"In cultured keratinocytes, exposure to increased glucose concentrations can cause activation of the NLRP3 inflammasome, which is inhibited by melatonin (Table 1)."
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"Here, we show that melatonin reduces oxidative stress and NLRP3 triggering due to activation of autophagic flux."
33353046
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"In addition, melatonin has been shown to inhibit activation of the NLRP3 inflammasome and pyroptosis in murine microglia by activating the SIRT1/Nrf2 signaling pathway [17]."
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"The results indicated that melatonin could attenuate prostate inflammation and pelvic pain by inhibiting the NLRP3 inflammasomes signaling pathway through the activation of Sirt1 in mice with EAP, and these efforts should provide a promising therapeutic strategy for CP/CPPS."
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"The evidence indicates that melatonin inhibits the activation of NLRP3 inflammasome in a mouse model of non-alcoholic steatohepatitis induced by high fat diet by inhibiting P2X7R receptors (Saha et al., 2022)."
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"Melatonin lowered NLRP3 protein to sham levels in WT mice, while in alpha7 nAChRs KO melatonin treated animals had significantly elevated NLRP3 expression compared to melatonin treated WT group (XREF_FIG D)."
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"Furthermore, study found that Polyphyllin VI (PPVI) promotes pyroptosis by activating the ROS/NFκB/NLRP3/caspase 1/GSDMD signal axis, which also suppressed the proliferation of NSCLC.As a common antioxidant, xuebin wang et al. found that melatonin could attenuate cigarette smoke (CS)-induced endothelial cell (EC) pyroptosis by inhibiting ROS/NLRP3 axis."
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"Furthermore, melatonin inhibited the NLRP3 inflammasome activation through the suppression of extracellular histone release [XREF_BIBR]."
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"Pretreatment of mice with melatonin before Cd exposure reduced ROS generation and abrogated the activation of NLRP3, the fundamental pathogenesis factor of cadmium, at the mRNA level."
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"Nevertheless , the downregulation of NLRP3 by melatonin through ROS scavenging seems to be involved in more researches ."
33777317
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"Moreover, in the irradiated RAW 264.7 cells, melatonin blocked the NLRP3 inflammasome activation accompanied with the inhibition of the IL-1beta release and caspase-1 activity."
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"Melatonin suppresses NLRP3 inflammasomes, proinflammatory cytokine activation and facilitates switching of highly inflammatory M1 macrophages to anti-inflammatory M2 macrophages [23–25] In numerous an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"They have extensively demonstrated that melatonin could inhibit the NLRP3 inflammasome pathway in radiation induced oral mucositis [XREF_BIBR] and cecal ligation induced sepsis [XREF_BIBR]."
30755784
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"Experiments by Huang et al. (2020a) showed that treatment with melatonin could reduce TNF-α-induced ECM destruction by inhibiting the activity of the NLRP3 inflammasome."
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"Western blot analysis showed that the expressions of NLRP3 and ASC significantly increased following 15Gy irradiation, whereas melatonin treatment markedly attenuated the NLRP3 and ASC activations compared with those vehicle treated."
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"* Melatonin : Melatonin has been shown to inhibit NFkB activation and NLRP3 inflammasome activation."
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"73 Melatonin inhibited the NLRP3/GSDMD pathway to eliminate LPS-induced alveolar injury, neutrophil infiltration, and pulmonary edema."
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"Of note, we have revealed that radiation induced NLRP3 inflammasome activation was attenuated by melatonin exposure, while this effect of melatonin was markedly negated by repressing miR-30e levels with its inhibitor in macrophages."
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"Moreover, melatonin has been shown to reduce inflammation and pelvic pain by activating the Sirt1 pathway and downregulating the NLRP3 inflammasome ."
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"[82] By modulating the expression of multiple proteins and the signaling processes that they engage in, melatonin suppresses the NLRP3 inflammasome."
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"How melatonin directly blocks activation of the NLRP3 inflammasome in ALI remains unclear."
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"Emerging evidence has shown that melatonin exerts a protective effect against SIMI via different pathways.93 Garcia et al revealed for the first time that melatonin inhibits the NF-kB/NLRP3 pathway through the retinoid-related orphan receptor (ROR)-α to recover normal mitochondrial function and cellular redox status against SIMI.43 Melatonin reduces NF-κB-mediated proinflammatory responses and boosts mitochondrial homeostasis and redox balance, inhibiting NLRP3 inflammasome activation."
39967903
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"Moreover, melatonin has been described as an endoplasmic reticulum stress mediator, promoting TRX1 activity by inhibiting the TXINP and NLRP3 pathway [XREF_BIBR]."
33321938
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"In conclusion, our study showed that melatonin inhibited the activation of the NLRP3 inflammasome in BEND cells through autophagy, which may provide a novel therapeutic strategy for bovine endometritis."
37570258
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"Thus, melatonin prevents the activation of the NLRP3 inflammasome and caspase-1, as well as IL-1β [35,38]."
38136651
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"Although not investigated in pancreatic β-cells, melatonin suppresses the NLRP3 inflammasome in different cell types across the body [179], indicating another aspect to melatonin’s potential utility in T1DM treatment, as well as from locally produced pancreatic melatonin.Stem cell development now allows for the priming of stem cells to have the contents of their exosome/vesicles shaped to provide targeted treatments (such as miRNAs and 14-3-3 proteins) to particular cells."
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"These data indicated that melatonin attenuated NLRP3 inflammasome in the lung tissues of rats with COPD via SIRT1 pathway.Numerous studies have demonstrated that melatonin plays a protective role in t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29990691
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"And colleagues found that melatonin could inactivate NF-kappaB induction , reduce NLRP3 expression and alleviate the inflammatory state of sepsis ( 77 ) ."
34305952
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"Findings from the rat SAH model suggest that melatonin inhibits NLRP3 activation by a mitophagy-mediated reduction in ROS [77]."
34202842
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"Recently, several studies have demonstrated that melatonin could inhibit the NLRP3 inflammasome during sepsis and mucositis [ 34 , 35 ]."
29990691
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"A recent study by our team has shown that melatonin injection inhibits LPS-induced depressive-like behavior in mice by downregulating NLRP3 activation in the brain [64]."
34202842
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"Qin et al reported that melatonin could inhibit the overactivity of NLRP3 inflammasome by enhancing mitochondrial autophagy and suppressing TLR4/NF-κB pathway activity."
39093737
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"Preceding studies reported that sirtuins attenuate NLRP3 inflammasome activation by deacetylating of NLRP3 protein [63], and melatonin increased SIRT1 activity to inhibit the NLRP3 inflammasome [62,64]."
34202842
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"Melatonin and Bifidobacterium suppress NLRP3 and caspase-1/11, alleviating fluoride- and 1,2-DCE-induced damage [140,141]."
| PMC
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"To further demonstrate whether melatonin inhibits the activation of the NLRP3 inflammasome, the protein expression of components of the NLRP3 inflammasome, including NLRP3, pro-IL-1β, IL-1β, ASC, caspase-1, and pro-caspase-1, was measured by western blotting."
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"Melatonin was shown to inhibit the increased activity of NLRP3 inflammasomes by both enhancing mitochondrial autophagy and inhibiting TLR4/NF-κB pathway activity."
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"Melatonin has also been shown to inhibit the NLR Family Pyrin Domain Containing 3 (NLRP3), an important inflammatory mediator known to reduce the inflammatory cascade for the synthesis of pro-inflamma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Melatonin could modulate inflammation by decreasing the activation of both NF-kappaB and inflammasomes NLRP3 (nucleotide binding domain leucine rich repeat (NLR) and pyrin domain containing receptor 3)."
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"Melatonin interacted with this pathway to inhibit the NLRP3 inflammasome through SIRT-1 and the modulation of micro-RNA expressions 41."
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"Melatonin reduces myocardial cell damage in myocardial ischemia/reperfusion rats by inhibiting NLRP3 activation."
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"Melatonin was demonstrated to reduce lipopolysaccharide (LPS)-induced inflammation and the formation of the NLRP3 inflammasome in mouse adipocytes, thus inhibiting caspase-1 and IL-1 activation and the NLRP3 inflammasome-mediated pyroptosis [31,32]."
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"Similarly, melatonin has been shown to prevent OSCC by regulating the MIF, NLRP3, and IL-1β pathway [251]."
39769450
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"In ovalbumin-induced airway inflammation in mice, intraperitoneal (IP) melatonin reduces the NLRP3 activation in lungs."
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"It was concluded that melatonin can inhibit NLRP3 by regulating non-coding RNAs and has an overall anti-inflammatory effect with the inhibition of inflammatory pathways, such as NFκB, and the activation of mitophagy and the Nrf2/NFE2L2 pathway, diminishing ROS generation."
35326182
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"In addition, some studies suggest that melatonin inhibit NLRP3 inflammasome by suppressing ROS production (58)."
36910525
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"Interestingly, melatonin has also been described to activate mitophagy in macrophages and reduce the activity of the NLRP3 inflammasome."
37201736
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"Furthermore , melatonin reduced expression of NLRP3 , ASC , cleaved caspase-1 , GSDMD , and cleaved GSDMD , and decreased the number of Iba1 / IL-1beta-positive cells ."
36031799
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"In many studies, melatonin was indicated to attenuate NLRP3 inflammasome due to its anti-inflammatory, antioxidative, and immunomodulatory effects [14,131]."
34202842
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"In mouse model systems, melatonin can inhibit the NLRP3 inflammasome, leading us and others to speculate a role for this inflammatory pathway in COVID-19."
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"Melatonin is able to effectively prevent the production of NLRP3 inflammasomes and reduce inflammation, both of which are connected to COVID-19."
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"Furthermore, melatonin was found to suppress the NLRP3/IL-1β axis and reduce eNOS proteolysis, resulting in improved endothelium-dependent vasorelaxation.78The LPS can directly cause endothelial cells (ECs) injury, disrupting the cytoskeletal proteins, intercellular connections, and adhesion of ECs, which leads to the increased vascular permeability and fluid extravasation into the extravascular tissue, resulting in edema."
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"In agreement with recent report that exogenous melatonin attenuates airway inflammation in rats with COPD via suppressing the activation of NLRP3 inflammasome [ 52 ], our present study demonstrated th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31738882
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"And this protective effect of CpG-ODN was attributed to the restored melatonin which inhibited the activation of NLRP3 inflammasome in the lung tissues."
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"Besides that, melatonin has been shown to inhibit the NLRP3 inflammasome component activation and pro-inflammatory cytokines IL-1β, IL-8, TNF-α, and IL-6 production in a high glucose-stimulated in vit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our mechanistic analyses revealed that melatonin indeed suppressed the NLRP3 axis, decreased VEGF and CXCL cytokine contents, and inhibited LECs tube formation in the A549/THP-1 co-culture system."
39230586
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"Melatonin inhibits the NLRP3 inflammasome via mitophagy, which reduces the size and vulnerability of AS plaques [107]."
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"Melatonin Promoted Mitophagy and Inhibited NLRP3 Inflammasome Activity in APP/PS1 Transgenic Mice."
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"Our study aimed to further demonstrate that MT inhibits NLRP3 in a corneal transplantation model , thereby affecting the migration of both innate and adaptive immune cells to the corneal and cervical lymph nodes , as well as the secretion of inflammatory factors and chemokines , thereby modulating the immune response to promote rejection after transplantation ."
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"In more detail, melatonin administration decreased NLR family pyrin domain containing 3 (NLRP3), p20, and IL-1β levels by inhibiting nuclear factor kappa B (NF-κB) signaling and downregulating mtROS production in human NP cells treated with IL-1β and a rat needle puncture IDD model."
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"Melatonin Improved Mitophagy and Inhibited the NLRP3 Inflammasome In Vitro."
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"In addition, studies have shown that CpG oligodeoxynucleotides (CpG‐ODN), 46 melatonin, abscisic acid (ABA) or foods rich in ABA can also inhibit the activation of NLRP3 inflammasome and delay the progression of airway inflammation."
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"MT can also significantly inhibit the gene expression of other NLRP3 regulatory proteins, such as NEK7 and P2rx7."
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"Moreover, compounds such as melatonin,108 hydnocarpin D,109 isoorientin,110 citrulline,111 and glycyrrhizic acid95 also inhibit NLRP3 inflammasome-mediated cell apoptosis through Nrf2, reducing LPS-induced ALI."
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"Previous in vitro and in vivo studies established that melatonin suppresses the NLRP3 inflammasome mainly by inhibition of NF-κB signaling, activation of SIRT1 and Nrf2 pathways, and inhibition of ROS production."
34202842
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"Melatonin inhibits the activation of NLRP3 inflammasome by mediating the Wnt and beta-catenin pathway in BMSCs from ovariectomized (OVX) mice, thereby enhancing osteoporosis in OVX treated mice [XREF_BIBR]."
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"Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice."
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"Moreover, MT inhibited the activation of the NF-kappaB pathway, and reduced the expression of inflammation related proteins (iNOS and COX-2), and pyroptosis related proteins (NLRP3, caspase-1, and GSDMD)."
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"Specifically, in rats with COPD, melatonin can inhibit the NLRP3 inflammasome and IL-1β, thus alleviating airway inflammation [62], suggesting that melatonin can delay the onset and development of COPD by acting against inflammation."
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"Melatonin inhibits NLRP3 inflammasome and pyroptosis with diminished caspase1, IL-1βand IL 18 production and suppressive NF-κB activation."
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"In vivo , melatonin reverted LPS-induced cognitive decline , reduced NLRP3 levels and promoted autophagic flux in the hippocampi of WT mice , whereas in alpha7 nAChR KO mice melatonin effect was not observed ."
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"Melatonin activated intracellular antioxidant thioredoxin‐1 and inhibited the activation of NLRP3 inflammasome that mediated by mitochondrial damage or endoplasmic reticulum stress."
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"Incidentally, in COVID-19, pyroptosis gives rise to exaggerated inflammation and melatonin can block pyroptosis by antagonizing NF-κB and NLRP3 signaling [33,34] ."
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"Melatonin reduced NLRP3 , caspase-1 and ASC speck formation ."
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"In addition, melatonin was found to inhibit the development of the NLRP3 inflammasome by suppressing extracellular histone release."
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"Beyond IL-18BP, the results from Xu et al. showed that Wnt/β-catenin signaling (participates in osteoblast differentiation) activated by melatonin could also inhibit NLRP3 inflammasome activity, weakening osteogenic differentiation and attenuating the bone loss [98]."
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"Inhibition of NLRP3 by MT prevented from the activation of pro-L-1beta and pro-IL-18 , thus blocking the initiation of proinflammatory cytokine cascade [ 82,83,84,85 ] ."
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"It has been demonstrated that MT also reduces the activation of NLRP3 inflammasomes in a number of conditions assessed (18)."
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"Consequently, melatonin mediated upregulation of proteins associated with mitophagy inhibited NLRP3 inflammasome activation and significantly reduced pro inflammatory cytokine levels after SAH."
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"In addition to inhibiting the NF-κB pathway, topical application of melatonin inhibits NLRP3 and mitochondrial dysfunction [57], thereby attenuating inflammatory cytokines."
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"Moreover, melatonin has anti-inflammatory properties, suppresses NLRP3 activation, cytokine release, and shifts microglia towards an M2 anti-inflammatory phenotype [158]."
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"Melatonin has been confirmed to inhibit the activation of the NLRP3 inflammasome in several animal models."
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"Melatonin has been shown to inhibit the activation of the NLRP3 inflammasome, thereby mitigating acute lung injury [25]."
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"Melatonin attenuates the expression of pyroptosis‐related genes, including NLRP3, ASC, cleaved‐caspase‐1, GSDMD, IL‐1β and IL‐18, in aortic endothelium."
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"Moreover, an in vitro study on murine microglia exhibited that melatonin inhibited the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activation and pyroptosis, which was substantially dependent on the crosstalk between NRF2 and SIRT1 [42]."
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"In endometritis, melatonin effectively reduces the production of pro-inflammatory factors (IL-1β, IL-6, and TNF-α) in endometrial epithelial cells by inhibiting the activation of the NLRP3 inflammasome (187)."
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"Besides, melatonin remarkably suppresses microglial activation and NLRP3 inflammasome activity, reduces DA neuron damage, and alleviates behavioral dysfunction via a silence information regulator 1-dependent pathway in MPTP-induced PD models [118]."
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"Compared with NPCs treated with hydrogen peroxide, pretreatment with melatonin significantly upregulated the expression of Nrf2 and downregulated the pyroptosis-related proteins NLRP3, cleaved CASP-1, GSDMD-N, IL-18, and IL-1β (Figures 3b and 3c)."
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"Combined with the report by Xu’s team [176], melatonin inhibits the activation of NLRP3 inflammasome through the Wnt/β-catenin pathway and improves OP and impaired osteogenic differentiation potential induced by estrogen deficiency."
39799353
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"Recent research has shown that melatonin could inhibit the hyperactivity of NLRP3 inflammasomes by enhancing mitochondrial autophagy and inhibiting TLR4/NF-κB pathway activity [27]."
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"In a scopolamine induced dry eye disease (DED) mouse model, intraperitoneal injection melatonin protects CECs from oxidative damage, maintains normal level of autophagy, inhibits the activation of NLR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, melatonin attenuated cigarette smoking-induced atherosclerosis by activating the Nrf2 signaling pathway and NLRP3 inflammasomes in endothelial cells [ 18 ]."
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"Melatonin also decreased NF-kappaB-dependent proinflammatory response and restored redox balance and mitochondrial homeostasis, thus inhibiting the NLRP3 inflammasome."
26045547
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"Melatonin induces the inhibitory function of the NLRP3 inflammasome by either inhibiting or activating several different proteins and pathways (122)."
38361952
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"One of the several proteins and pathways melatonin uses to inhibit NLRP3 activation is NF-kb signaling, a master regulator of the priming phase of NLRP3 inflammasome activation (34)."
38361952
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"Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) by Downregulating Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) Activity."
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"Melatonin was shown (in rats) to attenuate oxidative stress, NLRP3 inflammasome and apoptosis induced by CIN [155]."
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"Indeed, a great many studies in cells cultures or rodents have shown that melatonin can suppress the activation of NLRP3 inflammasomes [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Melatonin obviously decreased both NLRP3 and consequential caspase-1 activation , indicating that melatonin reduced ox-LDL-induced NLRP3 inflammasome activation ."
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"One clinical study on OLT1177 (NCT04540120) is being recruited to evaluate its safety and efficacy.In recent years, NLRP3 has been identified as a new target for melatonin action, and melatonin inhibits NLRP3 activity and IL‐1 production through multiple pathways."
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"Nevertheless, melatonin treatment inhibits NLRP3 activation and thus restores osteogenic capacity through the recognized osteogenic-related Wnt/β-catenin pathway [197] ."
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"Moreover, future work should address whether melatonin increases Nrf2 to deactivate the NLRP3 inflammasome during a viral infection at the maternal–fetal interface."
38361952
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"Garcia et al. reported that melatonin inhibits NF-kappaB and NLRP3 activation by regulating the retinoic acid receptor related orphan receptor alpha pathway [XREF_BIBR]."
32377306
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"Notably, melatonin treatment effectively suppressed the NLRP3/IL-1β axis and prevented eNOS proteolysis, thus alleviating sepsis-induced vascular dysfunction."
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"Thus, melatonin prevents the activation of the NLRP3 inflammasome and the formation of caspase 1 as well as IL-1β (Figure 3) [93]."
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"In a lipopolysaccharide (LPS)‐induced acute lung injury (ALI) mouse model, intratracheal administration of 30 mg/kg body weight melatonin 3 days before ALI induction improved histological changes in the lung caused by LPS stimulus, as well as lung density and aerated lung volume, and decreased the infiltration of macrophages and neutrophils and IL‐1β and caspase‐1 levels by inhibiting NLRP3 activation."
34861097
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"Nevertheless, the downregulation of NLRP3 by melatonin through ROS scavenging seems to be involved in more researches."
33777317
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"Melatonin has been reported to inhibit the activation of NLRP3 inflammasome in various diseases including atherosclerosis, sepsis, and also CNS diseases [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
33777317
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"Neurological benefit of NLRP3 inflammasome attenuation by melatonin was also found in LPS induced acute depressive like behaviors."
33777317
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"In the present study, melatonin was found to suppress the NLRP3/IL-1β axis and reduce eNOS proteolysis, leading to improved endothelium-dependent vasorelaxation in the aortic arteries of septic model [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33529913
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"In addition, melatonin was demonstrated to prevent eNOS proteolysis by inhibiting the activation of the NLRP3/IL-1β axis, thereby improving vasodilation, suggesting that melatonin may be a potential c[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33529913
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"Moreover, in MPP + -primed BV2 cells, melatonin markedly restored the downregulation of SIRT1 and attenuated the activation of the NLRP3 inflammasome."
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"In conclusion, our data demonstrated that melatonin attenuates neuroinflammation by negatively regulating NLRP3 inflammasome activation via a SIRT1 dependent pathway in MPTP induced PD models."
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"CRIDs/MCC950 and melatonin inhibits the NLRP3 components of the inflammasome, while melatonin additionally inhibits the production of ROS which contributes to inflammsome activation."
| PMC
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"Incidentally, in COVID-19, pyroptosis gives rise to exaggerated inflammation and melatonin can block pyroptosis by antagonizing NF-κB and NLRP3 signaling [33], [34]."
| PMC
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"Glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and NLRP3 inflammasome activation caused by bacterial toxin pyocyanin in colon."
33189867
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"53 A study by Ma and colleagues 54 found that melatonin could scavenge ROS and attenuate the activation of NLRP3 (nucleotide‐binding domain and leucine‐rich repeat pyrin domain containing 3) inflammatory vesicles through the Sirt3/FOXO3a/Parkin mitophagy pathway in macrophages, which in turn significantly attenuated the size and vulnerability of AS plaques for the purpose of treating AS."
37039609
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"A related study in cardiovascular disease labeled that melatonin and corticotropin blockade of NLRP3 inflammatory vesicles helped prevent septic responses in the hearts of septic mice."
38324950
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"Melatonin, by activating the α7nAChR receptor, inhibits the activation of NLRP3 by inhibiting the release of mitochondrial DNA [76]."
34201776
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"Studies showed that melatonin inhibited the activation of the NLRP3 inflammasome through the Sirt1/Nrf2 pathway ( Zhang et al., 2018 )."
36529253
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"Herein, we demonstrate that melatonin suppressed prolonged NLRP3 inflammasome activation in atherosclerotic lesions by reactive oxygen species (ROS) scavenging via mitophagy in macrophages."
30254716
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"In addition, relative to controls, melatonin administration strongly inhibited the NLRP3 inflammasome axis, as well as angiogenesis and lymphangiogenesis in the co-culture system."
39230586
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"Results also indicated that melatonin protects against mitochondrial dysfunction and inhibits the NLRP3/inflammasome pathway [136] ."
35623297
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"Our previous study has also demonstrated that melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis (11)."
36799176
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"Melatonin inhibited NLRP3 inflammasome activation and attenuated pro inflammatory cytokine secretion after SAH."
28546552
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"Melatonin suppressed angiogenesis and lymphangiogenesis via the NLRP3 inflammasomal axis ."
39230586
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"It was concluded that melatonin can inhibit NLRP3 by regulating non-coding RNAs and has an overall anti-inflammatory effect with the inhibition of inflammatory pathways , such as NFkappaB , and the activation of mitophagy and the Nrf2 / NFE2L2 pathway , diminishing ROS generation ."
35326182
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"We made the following observations : (1) treatment with melatonin upregulated mitophagy associated proteins (PINK1 and Parkin) and reduced mitochondrial damage and ROS generation after SAH; (2) administration of melatonin inhibited NLRP3 inflammasome activation after SAH and attenuated the inflammatory response; (3) melatonin treatment reduced neuronal cell death, brain edema and neurological dysfunction following SAH; and (4) pretreatment with 3-MA reversed the beneficial effect of melatonin on the inhibition of NLRP3 inflammasome activation."
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"Another 40 studies were reportedly withdrawn, without obvious reasons, but one might speculate that this was due to difficulties in recruiting patients or to the lack of results, particularly on delirium prophylaxis, Parkinson’s disease, coronary artery calcification, intensive care elderly population or “melatonin inhibition of NLRP3 inflammasome in COVID19 patients”, to name only but a few.Looking at the 56 trials currently recruiting, one can separate them into two main categories: observational and interventional."
37371523
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"Furthermore, melatonin decreased NLRP3 inflammasome activation and the consequent IL-1 beta secretion within atherosclerotic lesions."
30254716
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"Similar results were achieved in vivo where in wild-type mice , melatonin reverted cognitive decline , reduced NLRP3 levels , and increased autophagic degradation ."
35326182
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"Melatonin also promotes mitophagy and inhibits NLRP3 inflammasomes in DRG cells."
34398134
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"In ox-LDL-treated macrophages, melatonin attenuated the NLRP3 inflammasome activation and the inflammatory factors secretion, while this protective effect was abolished by either Sirt3 silence or autophagy inhibitor 3-MA."
30254716
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"3.4 Melatonin inhibits the M1-type activation of BV2 by inhibiting the activation of NF-kB and NLRP3."
38873431
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"While in the experimental autoimmune prostatitis (EAP) mouse model, apart from the attenuating effect of the NLRP3 inhibitor MCC950 (67), melatonin also inhibited the NLRP3 inflammasome signaling pathway by activating Sirt1, which reduced prostate inflammation and pelvic pain (68)."
36744134
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"Melatonin downregulated angiogenesis and lymphangiogenesis by targeting the NLRP3 pathway in mice ."
39230586
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"Melatonin can significantly inhibit the activation of NF-kB/NLRP3."
38873431
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"Melatonin inhibits NLRP3 inflammasome in the liver tissue of db/db mice."
34399601
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"Our previous report suggested that melatonin suppresses NLRP3 inflammasomal activation via oxidative stress inhibition [17]."
39230586
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"Our study aimed to further demonstrate that MT inhibits NLRP3 in a corneal transplantation model, thereby affecting the migration of both innate and adaptive immune cells to the corneal and cervical lymph nodes, as well as the secretion of inflammatory factors and chemokines, thereby modulating the immune response to promote rejection after transplantation."
34737710
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"At the same time, melatonin can inhibit TNF-α-mediated destruction of the IVD extracellular matrix by reducing the activity of the NLRP3 inflammasome in NP cells [80]."
36768679
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"Melatonin and miR-146a-5p, which inhibit the activation NLRP3, are promising therapeutic targets in NEC (112, 113)."
37841247
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"Besides, a recent study has shown that the anti-inflammatory drug melatonin inhibits NF-κB cascades and NLRP3 inflammasome, the two main pathways during SARS-CoV-2 infection."
34650550
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"Moreover, melatonin effectively reduced NLRP3 inflammasome triggering in RLE-6TN cells."
35109747
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"It is known that melatonin prevents the activation of NLRP3 inflammasome."
33848919
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"Melatonin inhibits ROS/NLRP3 inflammasome pathway in HUVECs under HG conditions by activating the Nrf2 pathway."
36799176
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"In this part of the experiment, in order to confirm that melatonin inhibits the activation of ROS/NLRP3 inflammasome pathway in vascular endothelial cells induced by HG mainly through or at least partly through Nrf2 signaling pathway, Nrf2 expression was knocked down by siRNA interference, which was verified by RT-qPCR."
36799176
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"Melatonin may reduce NLRP3 inflammasome activation by inhibiting oxidative stress and thus protect against injury from AFB1 induced myocardial toxicity."
33081548
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"Many in vitro and in vivo studies have shown that MT inhibits NLRP3 inflammasome activity via various intracellular signaling pathways (Ehirli et al., 2021)."
34737710
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"It has been demonstrated that melatonin could block the activation of the NLRP3 inflammasome in the prefrontal cortex of morphine-treated mice, while the knockdown or pharmacological inhibition of NLRP3 could abolish inflammasome activation in animals."
34399601
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"However, it is not clear whether MT plays a role in regulating the innate and adaptive immune responses during corneal graft rejection.Our study aimed to further demonstrate that MT inhibits NLRP3 in a corneal transplantation model, thereby affecting the migration of both innate and adaptive immune cells to the corneal and cervical lymph nodes, as well as the secretion of inflammatory factors and chemokines, thereby modulating the immune response to promote rejection after transplantation."
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