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USP4 inhibits cell differentiation. 5 / 5
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"Naive CD4 + T cells were sorted using flow cytometry based analysis and were induced for Th2 cell differentiation, and were treated with the inhibitor of USP4, vialinin A, and then processed by flow cytometry."
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"Accordingly, unlike our initial hypothesis on the role of USP4 in C2C12 cells, we found that USP4 suppresses differentiation of C2C12 myoblasts by reducing β-catenin stability.To investigate how USP4 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP4 suppresses Wnt3a induced osteoblast differentiation and mineralization by cleaving K63 linked polyubiquitin chains from disheveled (Dvl) and inhibiting the accumulation of beta-catenin and activation of its downstream cascades."
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"Inhibition of the catalytic activity of USP4 with vialinin A, an inhibitor of USP4 isolated from the Chinese mushroom, impairs Th17 differentiation, suggesting that USP4 promotes Th17 differentiation."
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"The role of USP4 in many pathological and physiological processes has been reported; USP4 promotes breast cancer invasive migration through the relaxin2-mediated TGF-β1/Smad2/MMP-9 pathway [31]; USP4 inhibits myogenic cell differentiation by catalyzing MyoD activity [32]; The H19/miR-148a/USP4 axis promotes hepatic stellate cells by enhancing and TGF-β signaling in hepatocytes to promote liver fibrosis [33]."
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