IndraLab

"The functional implications of BK channel lateral migration within the plasma membrane upon differential distribution of cholesterol between detergent-sensitive and detergent-resistant domains in mouse cerebral arteries, however, remains to be established.Current electrophysiological data also show that the slo1 channel Y450F substitution reduces the BK channel unitary current amplitude (Figure 2F), likely a consequence of Y450 being located next to the second Regulator of Conductance for the potassium (RCK) domain of the adjacent α subunit, in proximity to the inner leaflet and the calcium-sensing site."

"Glipizide or glibenclamide (Kir6.1-2; ATP-sensitive K+ channel blockers), tetraethylammonium or 4-aminopyridine (KV; voltage-gated K+ channel blockers) or charybdotoxin (KCa1.1; big conductance calcium-activated K+ channel blocker) or apamin (KCa2.1-3; small conductance Ca2+-activated K+ channel antagonist), or metformin, but not the opioid antagonists, reduced the antinociception of citral."

"In particular, mice‐lacking BK channel has reduced potassium content in their feces [31], and this channel is shown to be increased in colonocytes and crypt cells in ESKD patients compared to individuals with normal renal function [36]."