IndraLab

Statements

OTUB1 bound to Genome polyprotein inhibits Ubiquitin. 2 / 2
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"Juang et al. reported that OTUB1 is a lysine 48 linkage-specific deubiquitinating enzyme and elucidated the structural mechanism by which OTUB1 binds E2 ligases to inhibit ubiquitin transfer (7)."
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"The ability of OTUB1 to bind to E2 enzymes and inhibit ubiquitin transfer in a manner that does not depend on OTUB1 catalytic activity was first discovered in studies of DNA damage signaling, in which OTUB1 inhibits the E2, UBE2N/UBC13 (17)."
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