IndraLab

Statements


OTUB1 bound to E2 inhibits Ubiquitin. 2 / 2
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"OTUB1 binds to E2 ~ Ub thioester intermediates and prevent ubiquitin transfer, thereby non catalytically inhibiting accumulation of polyubiquitin."

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"The ability of OTUB1 to bind to E2 enzymes and inhibit ubiquitin transfer in a manner that does not depend on OTUB1 catalytic activity was first discovered in studies of DNA damage signaling, in which OTUB1 inhibits the E2, UBE2N/UBC13 (17)."