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USP14 increases the amount of NCOA4. 5 / 5
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"USP14, an initiator of ferritinophagy induction, upregulates NCOA4 levels in neurons [51]."
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"In an in vivo mouse MCAO/R model and an in vitro cytosolic oxygen–glucose deprivation/reperfusion model, USP14 was found to significantly upregulate NCOA4 levels."
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"Moreover, the use of IU1, an inhibitor of USP14, significantly reduced NCOA4 levels in neurons and inhibited ferritinophagy, thus reducing brain tissue damage after CIR [77]."
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"In addition, we identify USP14 from several DUBs as the initiator upregulating cytoplasmic NCOA4 levels in ischemic neurons, and discovered that inhibition of USP14 reduces NCOA4 expression and protec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, NCOA4 was reported to be upregulated by ubiquitin-specific peptidase 14 (USP14) in damaged neurons, and USP14 inhibition effectively decreased NCOA4 levels to suppress ferritinophagy-mediated ferroptosis."
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