IndraLab
Statements
reach
"To the best of our knowledge, at least nine DUBs, A20, CYLD, USP3, USP5, USP14, USP15, USP21, USP25, and USP27X, have been proposed to counteract the K63linked ubiquitination of RIG-I and, thereby attenuate downstream signaling and IFN-b production ( Table 1 and Figure 3 ) (58, 76, 93) ."
reach
"Consistent with the negative regulatory role of USP15 in RIG-I-mediated signaling, USP15 substantially reduced RIG-I polyubiquitination in cells transfected with plasmid encoding the WT ubiquitin and Lys63 mutant (Fig. 5a,b), but not in the mutant-Lys48-transfected cells (Fig. 5c), indicating that USP15 has DUB activity directed specifically towards the Lys63-linked polyubiquitin chains of RIG-I."