IndraLab

Statements

ATXN3 activates localization. 5 / 5
| 5
reach
"d Spinocerebellar ataxia type 3 (SCA3): CK2 associates to and phosphorylates ataxin-3, thus promoting its nuclear localization and stabilization, and enhancing the formation of inclusions."
33994545
reach
"Coiled-Coil Structures of SCA3 polyQ Proteins Promote Their Nuclear Localization."
30348793
reach
"The product of this gene, ataxin-3, associates to and is phosphorylated by CK2 175 (Fig. 3d ), which induces its nuclear localization and stabilization, and enhances the formation of inclusions."
33994545
reach
"Mapping studies showed that two regions of Atx3, the Josephin domain and the C-terminus, regulated heat shock induced nuclear localization."
19843543
reach
"More evidence is needed to establish the physiological role of USP10 phosphorylation in tumorigenesis.In the case of ATX3, phosphorylation at Ser340 and Ser352 by CK2 enhances its nuclear localization, aggregation, and stability, processes that play a major role in the development of spinocerebellar ataxia-3."
32512887