IndraLab

Statements

SEPSECS binds STAMBP. 7 / 7
| 7
sparser
"Moreover, the K63‐specific DUB AMSH‐LP was the most effective in hydrolysing polyubiquitin chains on phagosomes."
36281581
sparser
"USP14, for instance, has exo‐activity as it removes K48‐linked chains only from the distal end, producing exclusively mono‐ubiquitin moieties [ xref ]; whereas other DUBs including CYLD, USP9X, AMSH‐LP and A30 were shown to possess endo‐activity, cleaving longer ubiquitin chains from their substrates [ xref , xref ]."
25478702
sparser
"The oxyester bond linking maltoheptaose to the ubiquitin dimer or tetramer was hydroxylamine sensitive and could not be cleaved by the M1‐Ub‐specific deubiquitylase Otulin or the K63‐Ub‐specific deubiquitylase AMSH‐LP (Fig xref )."
35274759
sparser
"As a member of the JAMM family of DUBs, STAMBPL1 (also known as AMSH‐LP) specifically cleaves K63‐linked polyubiquitin on the substrates and plays a role in the regulation of mesenchymal phenotypes. [ xref , xref ] Consistently, in this study, STAMBPL1 was identified as a potential mesenchymal maintenance regulator in KIRC cells, whose silencing decreased mesenchymal markers level and induced immune response genes expression."
39527690
sparser
"Likewise, the closely related JAMM DUBs AMSH and AMSH‐LP (AMSH‐like protein) have been implicated as positive regulators in the bone morphogenetic protein (BMP) and TGFß responses respectively through their interaction with inhibitory I‐SMADs (61, 62)."
20073038
sparser
"Interestingly, the UbiCRest experiment showed that most ubiquitylation on the phagosome is removed by using the K63‐specific DUB AMSH‐LP."
36281581
sparser
"In these experiments, phagosomal extracts were treated with ubiquitin‐chain specific DUBs such as USP2 (unspecific), vOTU (unspecific), Otulin (specificity: M1/linear), Cezanne (specificity: K11> > K63), Trabid (specificity: K29, K33 > K63) or AMSH‐LP (specificity: K63) (Ritorto et al ,  xref ; Kristariyanto et al ,  xref ) and examined for the amount of monoubiquitin generated (Fig  xref )."
36281581