IndraLab

Statements

USP8 inhibits SMO. 4 / 11
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"USP8 is proposed to negatively regulate degradation of Smoothened (Smo) and Frizzled receptor (Fz) associated with the Hedgehog (Hh) and Wingless (Wnt) signaling pathways, respectively (see below)."
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"USP8 Prevents the Localization of Smo to the Early Endosome."
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"Moreover, we found that USP8 prevents Smo localization to early endosomes that are labeled with Rab5."
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"The stimulation of Hh promotes Smo deubiquitination by ubiquitin specific protease 8 (USP8), which blocks Smo endocytosis and enhances Smo cell surface accumulation XREF_BIBR XREF_BIBR."
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