IndraLab

Statements

ACSL5 activates USP29. 3 / 3
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"These data suggest that USP29 mediated MASLD by stabilizing ACSL5 and further activating FAO."
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"Intriguingly, the overexpression of ACSL5 reversed the aggravated effects of USP29 knockout on lipid deposition in hepatocytes treated with PAOA (Fig. 6B, C)."
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"To determine whether ACSL5 overexpression also reversed the role of USP29 knockout in MASLD in vivo, ACSL5 was overexpressed in USP29-KO mice by injecting AAV8-ACSL5 (Supplementary Fig. 7A)."
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