IndraLab

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Hydroxychloroquine inhibits Cell Survival. 12 / 12
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"We found that pre-treatment with 3-MA or HCQ significantly reduced cell viability in Iso-incubated HFDs with UVB irradiation ( Fig. 2 G)."
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"This analysis is also important to exclude the potential perturbation of cell viability by HCQ at the molecular level, as the activation of caspase 3 has been observed in cells treated with toxic doses of HCQ [34]."
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"However, HCQ and QC impair cell viability at high doses and inhibit RIG-I signaling activation and cellular pyroptosis."
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"Figure 1B shows that 100 μg/ml HCQ significantly reduced cell viability, and 10 μg/ml, 1 μg/ml and 0.1 μg/ml were noncytotoxic doses."
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"The chloroquine analogs amodiaquine (XREF_SUPPLEMENTARY) and hydroxychloroquine (XREF_SUPPLEMENTARY) significantly reduced cell viability in a concentration dependent manner similar to that of chloroquine, although amodiaquine was 2-3 times more potent in reducing cell viability by 50% (~ 15 muM) in comparison to chloroquine (~ 40 muM) and hydroxychloroquine (~ 50 muM)."
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"Chloroquine and its analog hydroxychloroquine, which block lysosome-autophagosome fusion and lysosomal function thus suppressing macroautophagy and chaperone mediated autophagy, can inhibit cancer cell survival under stress conditions 1."
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"We demonstrated that HCQ slightly inhibited T-cell and Jurkat cell viability with less than 10% reduction at 5x standard concentration (= 3000ng/ml) and less than 30% reduction over vehicle control at 25x standard concentration, indicating low toxicity of HCQ in those cells."
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"Results : Our data showed that HCQ diminished cell viability under 5 and 30 mM glucose contents."
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"In another study using PBMCs from patients with rheumatoid arthritis, HCQ reduced cell viability and osteoclastogenic gene expression (calcitonin receptor; TRAP; CTSK and MMP-9) when culturing in a medium containing M-CSF and RANKL (64)."
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"At 24 h, CQ and HCQ at 80 μM decreased cell viability to 60% and 62%, respectively."
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"The results showed that hydroxychloroquine significantly reduces renal dysfunction by reducing serum creatinine, reducing the expression of protein molecular-1 kidney damage (KIM-1), and improving HK-2 cell viability."
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"As shown in Figure 2A, the cell viability of HuCCT-1 and CCLP-1 cells was significantly inhibited by HCQ, and the IC50 of the two cell lines was 168.4 ± 23.4 μmol/L and 113.36 ± 14.06 μmol/L, respectively."
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