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"Discussion Distinct Neuronal Call Channel Subunits Comprise a Novel DHP Sensitive Subtype Our results demonstrate that the a, p subunit mediates DHP- sensitive, high voltage activated, long lasting Ca[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Together, this pattern of severely altered neuronal responses to physiological stimuli suggests that HPCA deficiency might inhibit voltage-dependent Ca channels or, alternatively, modify the mechanism of maintaining the membrane potential and thus affect cellular response to membrane depolarization.In summary, we have presented evidence to support biallelic mutations in HPCA as a cause of AR primary isolated dystonia."

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"The disease is genetically heterogeneous and is classified as episodic ataxia type 2 (EA2) when it is caused by a mutation in the CACNA1A gene, encoding the alpha 1A subunit of the P/Q-type voltage gated calcium channel Ca v 2.1."