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USP22 activates Hypertrophy. 3 / 3
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"In the current study, we show that the overexpression of USP22 induced by treatment with FO greatly improved Ang II-induced cardiac dysfunction, heart hypertrophy, inflammation, and fibrosis (Figures 1–4)."
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"Recent research has shown that USP22 protects against myocardial ischemia‒reperfusion injury (Ma et al., 2020), but it is still unknown how USP22 affects Ang II-induced cardiac remodeling and hypertrophy."
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"PAS staining results showed that USP22 deficiency attenuated the renal tubular hypertrophy and mesangial expansion of diabetic mice ( Fig. 9 C)."
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