IndraLab

Statements

YAP1 activates OTUB2. 4 / 4
| 4
reach
"Conversely, in VSMCs cotransfected with the OTUB2 siRNA (siOTUB2) and a YAP overexpression plasmid (pcYAP), the upregulation of YAP signifi-cantly increased calcium deposition and abrogated the anticalcification effects of OTUB2 knockdown (Figure S5F-H)."
39776804
reach
"We also found that knockdown or inhibition of YAP partly abrogated the procalcific effect of OTUB2 on VC models both in vivo and in vitro."
39776804
reach
"We performed functional rescue experiments to determine whether YAP mediates OTUB2-regulated VSMC osteogenic transdifferentiation."
39776804
reach
"YAP knockdown or inhibition effectively antagonized the OTUB2-mediated increase in osteogenic differentiation (Figure 4I, 4K and Figure S5E)."
39776804