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YAP1 activates OTUB2. 4 / 4
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"We performed functional rescue experiments to determine whether YAP mediates OTUB2-regulated VSMC osteogenic transdifferentiation."
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"YAP knockdown or inhibition effectively antagonized the OTUB2-mediated increase in osteogenic differentiation (Figure 4I, 4K and Figure S5E)."
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"Conversely, in VSMCs cotransfected with the OTUB2 siRNA (siOTUB2) and a YAP overexpression plasmid (pcYAP), the upregulation of YAP signifi-cantly increased calcium deposition and abrogated the anticalcification effects of OTUB2 knockdown (Figure S5F-H)."
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"We also found that knockdown or inhibition of YAP partly abrogated the procalcific effect of OTUB2 on VC models both in vivo and in vitro."
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