IndraLab

Statements

TNFAIP3 inhibits RIPK1. 7 / 7
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reach
"The results indicate that miR-98-5p interference and 3beta-hydroxycholest-5-en-7-one treatment significantly upregulated the low TNFAIP3 expression induced by LPS stimulation, thereby inhibiting TRAF6, RIP, NF-kappaB, IL-1beta, and TNF-alpha secretion."
32771556
sparser
"Downstream to Toll-like receptor 4 (TLR4) and tumor necrosis factor receptor 1 (TNFR1) the A20 complex inactivates TRAF6 and RIP1, repressing the NF- κ B signaling pathway [ xref , xref ]."
26576414
eidos
"Further , A20 increases the degradation of RIP1 by facilitating K48-linked ubiquitination of RIP1 ."
31312197
sparser
"Second, TNFAIP3 inactivates RIPK1, which regulates IκB kinase (IKK) [ xref ]."
32334614
sparser
"Together, our results indicated that following TNF‐induced, RelA‐responsive A20 expression in a subset of cells, A20 binds to and subsequently inhibits RIPK1‐RIPK3 complexes, thereby transiently protecting these cells from necroptosis."
33314666
sparser
"Therefore, A20 inactivates RIP1 via sequential deubiquitinase and E3 ligase activities ( xref )."
22435550
sparser
"A20 inhibits pro-necroptotic RIPK1-RIPK3 complexes."
25939025