IndraLab

Statements

TNFAIP3 inhibits RIPK1. 6 / 6
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sparser
"Together, our results indicated that following TNF‐induced, RelA‐responsive A20 expression in a subset of cells, A20 binds to and subsequently inhibits RIPK1‐RIPK3 complexes, thereby transiently protecting these cells from necroptosis."
33314666
eidos
"Further , A20 increases the degradation of RIP1 by facilitating K48-linked ubiquitination of RIP1 ."
31312197
sparser
"Therefore, A20 inactivates RIP1 via sequential deubiquitinase and E3 ligase activities ( xref )."
22435550
sparser
"Downstream to Toll-like receptor 4 (TLR4) and tumor necrosis factor receptor 1 (TNFR1) the A20 complex inactivates TRAF6 and RIP1, repressing the NF- κ B signaling pathway [ xref , xref ]."
26576414
sparser
"Second, TNFAIP3 inactivates RIPK1, which regulates IκB kinase (IKK) [ xref ]."
32334614
sparser
"A20 inhibits pro-necroptotic RIPK1-RIPK3 complexes."
25939025