IndraLab

Statements

OTUB1 binds CD44. 7 / 7
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sparser
"Interestingly, by co-immunoprecipitation assays, we found that CD44 also interacts with OTUB1 although the binding affinity between OTUB1 and CD44 is not very high ( xref )."
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sparser
"Studies have shown that the deubiquitinating enzyme OTUB1, which can bind the CD44 (cluster of differentiation-44), is recruited under the effect of removing the ubiquitin chain on SLC7A11 to prevent its degradation through the proteasome and improve its stability, thereby inhibiting the occurrence of ferroptosis in tumors ( xref )."
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sparser
"Although the direct interaction of CD44 and OTUB1 is much lower in comparison to OTUB1-xCT interaction, nevertheless, this three-protein complex is thought to stabilize xCT more effectively, possibly further enhancing chemoresistance."
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reach
"Although the direct interaction of CD44 and OTUB1 is much lower in comparison to OTUB1-xCT interaction, nevertheless, this three-protein complex is thought to stabilize xCT more effectively, possibly further enhancing chemoresistance.Another player involved in CD44v9-xCT complex stabilization is mucin 1 (MUC1) – a transmembrane glycoprotein commonly overexpressed in a plethora of cancers including lung, colon, breast, pancreatic and ovarian cancers (Chen et al., 2021; Figure 4A)."
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reach
"Interestingly, by co-immunoprecipitation assays, we found that CD44 also interacts with OTUB1 although the binding affinity between OTUB1 and CD44 is not very high (XREF_FIG)."
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biogrid
No evidence text available
30709928
reach
"Studies have shown that the deubiquitinating enzyme OTUB1, which can bind the CD44 (cluster of differentiation-44), is recruited under the effect of removing the ubiquitin chain on SLC7A11 to prevent its degradation through the proteasome and improve its stability, thereby inhibiting the occurrence of ferroptosis in tumors (Liu et al., 2019)."
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