IndraLab

Statements

3',5'-cyclic AMP inhibits HCN4. 2 / 2
| 2
reach
"In HCN4 channels, association with PEX5R antagonized the modulation of channel gating by cAMP very similar in extent to what was observed in HCN2 (values for DeltaV 1/2 by cAMP of 17.6 +/- 1.9 mV [n =[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19555650
reach
"While rodent TC neurons are dominated by strongly cAMP modulated HCN2 and HCN4 channels XREF_BIBR XREF_BIBR, IN revealed at strong mRNA expression of the cAMP inhibited HCN3 isoform XREF_BIBR and the thalamic isoform HCN4 XREF_BIBR, thereby potentially explaining the reduced cAMP-sensitivity of IN."
27121468