IndraLab

Statements

3',5'-cyclic AMP inhibits HCN4. 3 / 3
| 3
reach
"While rodent TC neurons are dominated by strongly cAMP modulated HCN2 and HCN4 channels XREF_BIBR XREF_BIBR, IN revealed at strong mRNA expression of the cAMP inhibited HCN3 isoform XREF_BIBR and the thalamic isoform HCN4 XREF_BIBR, thereby potentially explaining the reduced cAMP-sensitivity of IN."
27121468
reach
"In HCN4 channels, association with PEX5R antagonized the modulation of channel gating by cAMP very similar in extent to what was observed in HCN2 (values for DeltaV 1/2 by cAMP of 17.6 +/- 1.9 mV [n =[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19555650
reach
"CAMP relieves the autoinhibition of HCN4 channels."
38652080