IndraLab

Statements

USP18 activates TP53. 3 / 3
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"In a positive feedback loop, the ISG15 conjugation system is also upregulated by p53 ISGylation to further potentiate p53 transactivity and downregulated by USP18 mediated deISGylation of p53."
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"USP18 downregulates p21 by accumulating misfolded dominant negative p53, which inactivates wild-type p53 transactivation, leading to the upregulation of key enzymes involved in de novo dNTP biosynthesis pathways and inactivated SAMHD1."
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"In functional studies, depletion of Usp18 could stimulate the p53 and caspase 3 protein levels."
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