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YOD1 binds Circulin-C. 28 / 28
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"Compared to controls, we found that the related expression of circ-YOD1 was significantly increased in CAD patients, but hsa-miR-21-3p and hsa-miR-296-3p were reduced (Fig.  xref )."
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"Therefore, we hypothesized that circ-YOD1 could play a negative regulatory role on miR-21-3p/miR-296-3p expression in CAD."
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"After transfection with siRNA or the circ-YOD1 overexpression vector, circ-YOD1 expression was identified using qRT-PCR in THP-1 cells and HASMCs (Fig.  xref )."
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"Accordingly, downregulation of circ-YOD1 expression could reduce the expression of BCL6 , FBXL18 , MMP9 and FCGR3B as shown by transfecting THP-1 cells and HASMCs with siRNAs (Fig.  xref )."
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"The result of ROC curve analysis showed that the 95% confidence interval (CI) of circ-YOD1 was 0.745–0.904, and the AUC was 0.824."
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"The results of pairwise comparison showed a statistically significant difference for circ-YOD1 ( P YOD1-21  < 0.01; P YOD1-296  < 0.05, Fig.  xref )."
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"Then, the expression levels of miR-21-3p and miR-296-3p were downregulated significantly in the overexpression circ-YOD1 group compared to the negative control."
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"Accordingly, downregulation of circ-YOD1 expression could increase the expression of miR-21-3p and miR-296-3p as analyzed after transfecting THP-1 cells and HASMCs with siRNAs against circ-YOD1 (Fig.  xref )."
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"Thus, we performed an integrated bioinformatic analysis and speculated that circ-YOD1 may serve as a diagnostic or prognostic biomarker of CAD and have potential therapeutic value."
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"Thus, Circ-YOD1 may regulate parental gene YOD1 expression that leads to CAD."
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"Two of these miRNAs were related to CAD xref , xref and can be regulated by circ-YOD1."
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"The expression level of Circ-YOD1 is significantly elevated in patients with CAD, and it regulates the expression of miRNAs (such as hsa-miR-21-3p and hsa-miR-296-3p), thereby affecting the expression of genes related to CAD (such as BCL6, FBXL18, MMP9, and FCGR3B) that play key roles in the pathogenesis of CAD [ xref ]."
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"These results indicate that circ-YOD1 may be a good predictive candidate biomarker for the diagnosis of CAD."
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"The expression levels of BCL6 , FBXL18 , MMP9 and FCGR3B were significantly upregulated in the overexpression circ-YOD1 group compared with the negative control."
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"Second, without a sufficient luciferase assay, we only identified circ-YOD1 as a biomarker for CAD."
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"Miao et al. analyzed 7 CAD-related microarray datasets and found that circ-YOD1 was significantly increased in CAD patients."
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"Further study revealed that circ-YOD1 promoted the expression of MMP9 and BCL6 by sponging hsa-miR-21-3p and hsa-miR-296-3p in THP-1 cells and HASMCs, respectively."
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"The area under ROC curve (AUC) of circ-YOD1 was 0.824, the AUC of hsa-miR-21-3p was 0.731 and hsa-miR-296-3p was 0.776."
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"For example, circ-YOD1 was considered as a biomarker for coronary artery disease [ xref ], and circDLPAG4 was identified as a potential therapeutic target for myocardial ischemia [ xref ]."
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"Miao et al. established a triple regulatory network of circRNA-miRNA-mRNA and found circ-YOD1 could be a good marker to predict the onset of CAD [ xref ]."
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"In addition, bioinformatics analyses have constructed circRNA-miRNA-mRNA regulatory networks, revealing the involvement of circRNAs such as circ-YOD1 in lipid metabolism and protein modification, further supporting their diagnostic and prognostic potential ( xref , xref )."
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"In addition, the area under the ROC curve of circ-YOD1 was 0.824, which suggested that circ-YOD1 could act as a novel biomarker for CAD [ 114 ]."
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"The pairwise comparison results showed that circ-YOD1 had statistical significance ( P YOD1-21  < 0.01 and P YOD1-296  < 0.05)."
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"The results of functional enrichment analysis of interacting genes and microRNAs showed that the shared circ-YOD1 may act as a new biomarker for CAD."
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"Several other specific conditions, such as coronary artery disease and nonvalvular persistent atrial fibrillation, have been associated with circRNAs, suggesting, respectively, that circ-YOD1 is a potential biomarker [ xref ] and that circRNA002085 and circRNA001321 show evidence of circRNA-associated ceRNA mechanisms [ xref ]."
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"A diagnostic experimental study, including 1842 patients and 316 controls, showed that circ-YOD1 may act as a new biomarker for CAD (AUC = 0.824) ( xref )."
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"Our investigation of the triple regulatory networks of circRNA-miRNA-mRNA in CAD revealed circ-YOD1 as a potential biomarker for CAD."
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"The head-to-tail splicing in the RT-qPCR product of circ-YOD1 was confirmed by Sanger sequencing and is shown in Fig.  xref ."
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