IndraLab

Statements

KCNH1 activates KCN. 3 / 3
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"In this work, we studied the localization and function of the human KCNH1 (MIM *603305), a voltage-activated potassium channel, in human dermal fibroblasts and hTERT RPE-1 cells."
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"It is a syndromic neurodevelopmental disorder that shared notable phenotypic overlaps with the syndrome caused by variants of potassium channel-encoding genes KCNN3 and KCNH1 (Gripp et al., 2021)."
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"This is demonstrated by experiments using MCF-7 breast cancer cells, in which application of the selective inhibitor E4031 has identified a distinct role for hERG in volume regulation that is separate from the proliferation mediated by the closely related human ether-a-go-go gene (hEAG) potassium channel 9."
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