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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Mutated CYLD inhibits NFkappaB. 2 / 2

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"Furthermore, nuclear translocation of Bcl-3, a component of reported NPC associated activated NF-kappaB signal p50/p50/Bcl -3, was inhibited upon CYLD WT expression, but not by CYLD mutants (XREF_SUPPLEMENTARY)."

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"Surprisingly, a non cleavable CYLD mutant does not impair TCR dependent canonical NF-kappaB activation, but does block activation of JNK, a critical step in TCR induced stimulation of multiple transcription factors and production of IL-2."

21868762

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...