IndraLab

Statements

CAST increases the amount of ATXN3. 2 / 2
| 2
reach
"Calpeptin (a calpain inhibitor) decreased levels of atxn3 cleaved fragments in atxn3-84Q zebrafish and rescued the motor phenotype, but it also removed all ATXN3 expanded protein due to an increase in autophagic flux (indicated by reduced p62 levels and increased LC3II levels) that cleared autolysosomes."
| PMC
reach
"Oral administration of the calpain inhibitor BDA-410 decreased both fragments formation and full-length ataxin-3 levels, reduced aggregation of mutant ataxin-3 and prevented cell injury and striatal and cerebellar degeneration."
24817574