IndraLab

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USP3 leads to the deubiquitination of MYCN. 2 / 2
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"The known role of ALYREF as a regulator of DNA binding guided further analyses that uncovered ALYREF-MYCN interaction in a nuclear coactivator complex which stimulates transcription of the ‘ubiquitin specific peptidase 3′ (USP3), consequently reducing MYCN ubiquitination and degradation."
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"We show that increased <span class="match term0">USP3</span> levels reduce K-48- and K-63-linked ubiquitination of <span class="match term1">MYCN</span>, thus driving up <span class="match term1">MYCN</span> protein stability"
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